Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus

被引：0

作者：

Catrin Sinner

Stefan T. Kaehler

Athineos Philippu

Nicolas Singewald

机构：

[1] Department of Pharmacology and Toxicology,

[2] University of Innsbruck,undefined

[3] Peter-Mayr-Strasse 1,undefined

[4] 6020 Innsbruck,undefined

[5] Austria,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2001年 / 364卷

关键词：

Locus coeruleus Serotonin Nitric oxide NO donor L-NAME Noise stress Tail pinch Push-pull superfusion;

D O I：

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学科分类号：

摘要：

Serotonergic mechanisms within the locus coeruleus (LC) are thought to be important in various functions including the stress response. In this study we investigated a possible role of nitric oxide (NO) as an intermediary messenger in the regulation of the serotonin (5-HT) neurotransmission within the LC. Using the push-pull superfusion technique coupled with HPLC and electrochemical detection, the in vivo release of 5-HT was determined in time periods of 10 min in the LC of freely moving rats.

引用

页码：105 / 109

页数：4