Role of eating disorders-related polymorphisms in obesity pathophysiology

被引：0

作者：

Carolina Ferreira Nicoletti

Heitor Bernardes Pereira Delfino

Flávia Campos Ferreira

Marcela Augusta de Souza Pinhel

Carla Barbosa Nonino

机构：

[1] University of São Paulo,Department of Internal Medicine, Ribeirao Preto Medical School

[2] São José do Rio Preto Medical School,Laboratory of Studies in Biochemistry and Molecular Biology, Department of Molecular Biology

[3] University of São Paulo,Department of Health Sciences, Ribeirão Preto Medical School – FMRP/USP – Laboratory of Nutrigenomic Studies

来源：

Reviews in Endocrine and Metabolic Disorders | 2019年 / 20卷

关键词：

Obesity; Food intake; Eating disorders; Binge eating disorder (BED); Bulimia nervosa (BN); Polymorphism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Human biological system provides innumerable neuroendocrine inputs for food intake control, with effects on appetite’s modulation and the satiety signs. Its regulation is very complex, engaging several molecular interactions with many tissues, hormones, and neural circuits. Thus, signaling molecules that control food intake are critical for normal energy homeostasis and a deregulation of these pathways can lead to eating disorders and obesity. In line of this, genetic factors have a significantly influence of the regulation of neural circuits controlling the appetite and satiety pathways, as well as the regulation of brain reward systems. Single Nucleotide Polymorphisms (SNPs) in genes related to hypothalamic appetite and satiety mechanisms, further in multiple neurotransmitter systems may contribute to the development of major Eating Disorders (EDs) related to obesity, among them Binge Eating Disorder (BED) and Bulimia Nervosa (BN), which are discussed in this review.

引用

页码：115 / 125

页数：10

共 461 条

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