Tamoxifen and the Farnesyl Transferase Inhibitor FTI-277 Synergize to Inhibit Growth in Estrogen Receptor-Positive Breast Tumor Cell Lines

被引：0
作者：
Chad A. Ellis
Michele D. Vos
Meredith Wickline
Christine Riley
Teresa Vallecorsa
William G. Telford
JoAnne Zujewski
Geoffrey J. Clark
机构：
[1] NCI,Department of Cell and Cancer Biology
[2] MB FACS Core,undefined
来源：
Breast Cancer Research and Treatment | 2003年 / 78卷
关键词：
apoptosis; breast; farnesyl transferase inhibitor; Ras; tamoxifen;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Farnesyl transferase inhibitors (FTIs) serve to specifically inhibit farnesyl isoprenoid lipid modification of proteins. Although originally developed as anti-Ras oncoprotein drugs, it now appears that these compounds function independently of Ras. FTIs have been shown to inhibit transformation by a variety of mechanisms, including apoptosis involving cytochrome c release from mitochondria.
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页码：59 / 67
页数：8
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