PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

被引：0
作者：
Lata Mukundan
Justin I Odegaard
Christine R Morel
Jose E Heredia
Julia W Mwangi
Roberto R Ricardo-Gonzalez
Y P Sharon Goh
Alex Red Eagle
Shannon E Dunn
Jennifer U H Awakuni
Khoa D Nguyen
Lawrence Steinman
Sara A Michie
Ajay Chawla
机构：
[1] Metabolism and Gerontology,Division of Endocrinology, Department of Medicine
[2] Stanford University School of Medicine,Department of Pathology
[3] Stanford University School of Medicine,Department of Genetics
[4] Graduate Program in Biomedical Sciences,Department of Neurology and Neurological Studies
[5] Baylor Institute for Immunology Research,undefined
[6] Baylor University,undefined
[7] Graduate Program in Immunology,undefined
[8] Stanford University School of Medicine,undefined
[9] Stanford University School of Medicine,undefined
[10] Stanford University School of Medicine,undefined
来源：
Nature Medicine | 2009年 / 15卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Macrophages coordinate the disposal of apoptotic cells. Ajay Chawla and his colleagues show that PPAR-δ, a sensor of fatty acids, is involved in this process. Ingestion of apoptotic cells by macrophages prompts the upregulation of PPAR-δ, which then responds by enhancing the expression of opsonins. Lack of PPAR-δ reduces apoptotic cell clearance and predisposes to autoimmunity (pages 1246–1248).
引用
收藏
页码：1266 / 1272
页数：6
相关论文
共 101 条
  • [1] Savill J(2000)Corpse clearance defines the meaning of cell death Nature 407 784-788
  • [2] Fadok V(2001)The phosphatidylserine receptor: a crucial molecular switch? Nat. Rev. Mol. Cell Biol. 2 627-633
  • [3] Henson PM(2002)A blast from the past: clearance of apoptotic cells regulates immune responses Nat. Rev. Immunol. 2 965-975
  • [4] Bratton DL(2004)Clearance of apoptotic cells: getting rid of the corpses Mol. Cell 14 277-287
  • [5] Fadok VA(2008)Clearance of apoptotic cells by phagocytes Cell Death Differ. 15 243-250
  • [6] Savill J(2007)Engulfment of apoptotic cells: signals for a good meal Nat. Rev. Immunol. 7 964-974
  • [7] Dransfield I(2007)Identification of Tim4 as a phosphatidylserine receptor Nature 450 435-439
  • [8] Gregory C(1998)Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies Nat. Genet. 19 56-59
  • [9] Haslett C(2001)Phagocytosis and clearance of apoptotic cells is mediated by MER Nature 411 207-211
  • [10] Lauber K(2002)Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase J. Exp. Med. 196 135-140
12345678910