Cobalt-catalyzed atom-economical, diastereo- and enantioselective coupling of aldimines and cyclopropanols

被引：0

作者：

Zhikun Liang

Qinglei Chong

Fanke Meng

机构：

[1] Chinese Academy of Sciences,State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences

来源：

Science China Chemistry | 2021年 / 64卷

关键词：

cobalt; enantioselective catalysis; homoenolate; Mannich reaction; cyclopropanol;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Catalytic generation of cobalt enolates through ring-opening of easily accessible cyclopropanols, subsequent β-hydride elimination and site-selective reinsertion followed by diastereo- and enantioselective additions to aldimines is presented. Such a process represents an unprecedented reaction pathway of cobalt homoenolates, affording a wide range of β-amino-ketones in up to 95% yield, 90:10 dr and 99:1 er without the need of any stoichiometric amount of additive or reagent.

引用

页码：1750 / 1755

页数：5

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