Unwrapping Neurotrophic Cytokines and Histone Modification

被引:0
作者
Cieron Roe
机构
[1] Brighton and Sussex Medical School,
来源
Cellular and Molecular Neurobiology | 2017年 / 37卷
关键词
Neurotrophic cytokines; Histone modification; Myelination; Epigenetics; Therapy; Neurodegeneration; Oligodendrocytes;
D O I
暂无
中图分类号
学科分类号
摘要
The conventional view that neuroinflammatory lesions contain strictly pro- and anti-inflammatory cytokines is being challenged. Some proinflammatory products e.g. TNF-α are crucial intermediates in axon regeneration, oligodendroglial renewal and remyelination. A more functional system of nomenclature classifies cytokines by their neuro ‘protective’ or ‘suppressive’ properties. Beyond the balance of these ‘environmental’ or ‘extrinsic’ signals, specific ‘intrinsic’ determinants of cytokine signalling appear to influence the outcome of axoglial regeneration. In this commentary, we examine the potential importance of cytokine-induced histone modification on oligodendrocyte differentiation. Neuroinflammation mediates the release of astrocytic leukaemia inhibitory factor (LIF) and erythropoietin (EPO) which potentiates oligodendrocyte differentiation and myelin production. Meanwhile, histone deacetylation strongly suppresses important inhibitors of oligodendrocyte differentiation. Given that LIF and EPO induce histone deacetylases in other systems, future studies should examine whether this mechanism significantly influences the outcome of cytokine-induced remyelination, and whether epigenetic drug targets could potentiate the effects of exogenous cytokine therapy.
引用
收藏
页码:1 / 4
页数:3
相关论文
共 89 条
[1]  
Cervellini I(2013)Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor Mol Med 19 223-229
[2]  
Annenkov A(2010)Regulation of oligodendrocyte differentiation and myelination Science 330 779-782
[3]  
Brenton T(2014)Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor Glia 62 272-283
[4]  
Chernajovsky Y(2006)Astrocytes promote myelination in response to electrical impulses Neuron 49 823-832
[5]  
Ghezzi P(2009)Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve J Neurosci Res 87 3343-3355
[6]  
Mengozzi M(2009)Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration Nat Neurosci 12 815-817
[7]  
Emery B(2010)Epigenetic regulation of oligodendrocyte identity Trends Neurosci 33 193-201
[8]  
Fischer R(2007)The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory J Neurosci 27 7339-7343
[9]  
Wajant H(2002)Histone deacetylase activity is necessary for oligodendrocyte lineage progression J Neurosci 22 10333-10345
[10]  
Kontermann R(2007)The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation J Biol Chem 282 6696-6706