Effects of Unpredictable Chronic Mild Stress on the Effects of Antidepressants in the Forced Swimming Test

被引：0
作者：
Kudryashov N.V. [1 ]
Kalinina T.S. [1 ]
Voronina T.A. [1 ]
机构：
[1] Zakusov Research Institute of Pharmacology, Moscow
来源：
Neuroscience and Behavioral Physiology | 2016年 / 46卷 / 6期
关键词：
antidepressants; chronic mild stress; mouse;
D O I：
10.1007/s11055-016-0284-z
中图分类号：
学科分类号：
摘要：
The effects of unpredictable chronic mild stress on the effects of the tricyclic antidepressant amitriptyline (10 mg/kg) and the selective serotonin reuptake inhibitor fluoxetine (20 mg/kg) in the Porsolt test were studied in male mongrel mice. Single doses of fluoxetine given after 14-day chronic mild stress lacked any antidepressant effect, while subchronic administration for 14 days strengthened depressive-like reactions. After stress for 28 days, the antidepressant effect of fluoxetine was present regardless of the number of doses given. Amitriptyline showed antidepressant activity independently of the duration of stress and the administration regime, though the presence of stress decreased the intensity of the antiimmobility effect. Thus, the number of doses and the duration of unpredictable mild stress are parameters determining the efficacy of antidepressants in the forced swimming test. © 2016, Springer Science+Business Media New York.
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页码：601 / 605
页数：4
相关论文
共 30 条
  • [1] Andreatini R., Depression and the hypothalamic-pituitary-adrenal axis: increasing the scope, Acta Neuropsychiatrica, 24, pp. 1-3, (2012)
  • [2] Castagne V., Porsolt R., Moser P., Early behavioral screening for antidepressants and anxiolytics, Drug Dev. Res., 67, pp. 729-742, (2006)
  • [3] Castaneda A.E., Tuulio-Henriksson A., Marttunen M., Et al., A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults, J. Affect. Disord., 106, pp. 1-27, (2008)
  • [4] Ciraulo D., Shader R., Pharmacotherapy of Depression, (2011)
  • [5] Gavish M., Bachman I., Shoukrun R., Et al., Enigma of the peripheral benzodiazepine receptor, Pharmacol. Rev., 51, 4, pp. 629-650, (1999)
  • [6] Gorman J., Docherty J., A hypothesized role for dendritic remodeling in the etiology of mood and anxiety disorders, J. Neuropsychiatry Clin. Neurosci., 22, 3, pp. 256-264, (2010)
  • [7] Griffin L., Mellon S., Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes, Proc. Natl. Acad. Sci. USA, 96, 23, pp. 13,512-13,517, (1999)
  • [8] Gronli J., Chronic Mild Stress – an Animal Model of Depression: from Behavior to Molecules, (2006)
  • [9] Gunn B., Brown A., Lambert J., Belelli D., Neurosteroids and GABAA receptor interactions: a focus on stress, Neuroscience, 5, (2011)
  • [10] Heinzmann J., Knapman A., van Nieuwenhuijzen P., Et al., Fluoxetine impacts hypothalamic-pituitary-adrenal axis regulation and changes stress-coping behaviour in mice selectively bred for extremes in stress reactivity, Pharmacopsychiatry, 21, (2011)
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