Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters

被引：0
作者：
M. Rosa Boleda
Élida Alechaga
Encarnación Moyano
M. Teresa Galceran
Francesc Ventura
机构：
[1] Aigües de Barcelona,Department of Analytical Chemistry
[2] University of Barcelona,Department of Environmental Chemistry
[3] IDAEA-CSIC,undefined
来源：
Environmental Science and Pollution Research | 2014年 / 21卷
关键词：
Pharmaceuticals; ATC code; FDW; LC-MS/MS; LC-HRMS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fifty samples of finished drinking waters (FDWs) from Spain covering 12 million inhabitants were tested for 53 pharmaceuticals pertaining to 12 different Anatomical Therapeutic Chemical (ATC) classification system codes. The studied compounds are a combination of most commonly consumed pharmaceuticals with other barely reported in the literature. Five compounds, azithromycin, clarithromycin, erythromycin, sulfamethoxazole, and ibuprofen were tentatively identified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in some samples (2 to 15 %), but only ibuprofen and azithromycin could be confirmed when analyzed by liquid chromatography–high-resolution mass spectrometry (LC-HRMS) with a quadrupole-Orbitrap instrument. Concentration levels of ibuprofen in the positive samples ranged from 12 to 17 ng/L (n = 6) while for azithromycin values from 5 to 9.5 ng/L (n = 3) were found. Ibuprofen fragmentation behaviour in different mass spectrometry instrument configurations (triple quadrupole, quadrupole-ion trap, and quadrupole-Orbitrap) was evaluated.
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页码：10917 / 10939
页数：22
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