Substituted quinolinones. 18. 3-Acetyl-4-methylthioquinolin-2(1H)-one as useful synthon intermediate for synthesis of some new quinolinones

被引：0

作者：

Mohamed M. Hassan

Elham S. Othman

Mohamed Abass

机构：

[1] Ain Shams University,Faculty of Education, Department of Chemistry

[2] College of Engineering,Basic Science Unit

[3] Majmaah University,undefined

来源：

Research on Chemical Intermediates | 2013年 / 39卷

关键词：

Quinolinone; Phase transfer catalysis; Vilsmeier reaction; Nucleophilic condensation; Annellation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3-Acetyl-4-methylthioquinolin-2(1H)-one (3) has been prepared and its reactivity towards treatment with different reagents, dilute sulfuric acid, aqueous sodium hydroxide, and hydrogen peroxide, is described. The reactions of compound 3 with benzylamine, benzaldehyde, DMF-DMA, Vilsmeier-Haack reagent, 2-chloro-3-formyl-pyridopyrimidone and malononitrile have been carried out under convenient conditions. Compound 3 underwent heterocyclization reactions with some binucleophiles, hydrazine, hydroxylamine, urea, thiourea, semicarbazide, and thiosemicarbazide, furnishing some known five, six, and seven heterocyclic annellated quinolines. All the new compounds have been characterized using different spectral and analytical tools.

引用

页码：1209 / 1225

页数：16

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