Focusing on the Pharmacological Effects of Iridoids and Crocetin and Its Ester Derivatives of Gardenia jasminoides

被引：0
作者：
Wang M. [1 ]
Li S. [2 ,3 ]
Lange K.W. [4 ]
Zhao H. [1 ]
机构：
[1] Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, No. 409 Guangrong Rd., Beichen Dist., Tianjin
[2] Hubei Key Laboratory of EFGIR, Huanggang Normal University, Huanggang, 438000, Hubei
[3] Department of Food Science, Rutgers University, New Brunswick, 08901, NJ
[4] Department of Experimental Psychology, University of Regensburg, Regensburg
来源：
Current Pharmacology Reports | 2019年 / 5卷 / 3期
基金：
中国国家自然科学基金;
关键词：
Crocetin; Crocin; Gardenia jasminoides; Genipin; Geniposide; Iridoid;
D O I：
10.1007/s40495-019-00177-6
中图分类号：
学科分类号：
摘要：
Gardenia jasminoides (G. jasminoides), grown in multiple regions in China, was commonly used as a natural yellow dye but has been one of the popular traditional Chinese medicines since the discovery of its biological property few decades ago. It has been reported that G. jasminoides possesses multiple bioactivities, such as anti-oxidant property, hypoglycemic effect, and inhibition of inflammation, anti-depression, and improving sleeping quality. In this review, we aimed to have a comprehensive summary of its phytochemistry including the extraction, isolation, and characterization of volatiles and bioactive molecules in G. jasminoides, focusing on the two major phytochemicals, iridoids and crocetin, and its ester derivatives, which exhibit potential medicinal properties. Furthermore, this work attempted to establish a structure activity relationship (SAR) between the two major series of derivatives with different molecular skeletons and their biological activities, which would serve further exploration of the health-promoting potentials of phyto-compounds in G. jasminoides as dietary supplements or functional ingredients in medical foods. © 2019, Springer Nature Switzerland AG.
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页码：150 / 162
页数：12
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