Focusing on the Pharmacological Effects of Iridoids and Crocetin and Its Ester Derivatives of Gardenia jasminoides

被引：0
作者：
Wang M. [1 ]
Li S. [2 ,3 ]
Lange K.W. [4 ]
Zhao H. [1 ]
机构：
[1] Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, No. 409 Guangrong Rd., Beichen Dist., Tianjin
[2] Hubei Key Laboratory of EFGIR, Huanggang Normal University, Huanggang, 438000, Hubei
[3] Department of Food Science, Rutgers University, New Brunswick, 08901, NJ
[4] Department of Experimental Psychology, University of Regensburg, Regensburg
来源：
Current Pharmacology Reports | 2019年 / 5卷 / 3期
基金：
中国国家自然科学基金;
关键词：
Crocetin; Crocin; Gardenia jasminoides; Genipin; Geniposide; Iridoid;
D O I：
10.1007/s40495-019-00177-6
中图分类号：
学科分类号：
摘要：
Gardenia jasminoides (G. jasminoides), grown in multiple regions in China, was commonly used as a natural yellow dye but has been one of the popular traditional Chinese medicines since the discovery of its biological property few decades ago. It has been reported that G. jasminoides possesses multiple bioactivities, such as anti-oxidant property, hypoglycemic effect, and inhibition of inflammation, anti-depression, and improving sleeping quality. In this review, we aimed to have a comprehensive summary of its phytochemistry including the extraction, isolation, and characterization of volatiles and bioactive molecules in G. jasminoides, focusing on the two major phytochemicals, iridoids and crocetin, and its ester derivatives, which exhibit potential medicinal properties. Furthermore, this work attempted to establish a structure activity relationship (SAR) between the two major series of derivatives with different molecular skeletons and their biological activities, which would serve further exploration of the health-promoting potentials of phyto-compounds in G. jasminoides as dietary supplements or functional ingredients in medical foods. © 2019, Springer Nature Switzerland AG.
引用
收藏
页码：150 / 162
页数：12
相关论文
共 89 条
  • [1] Yin F., Liu J.H., Research and application progress of Gardenia jasminoides, Chin Herb Med, 4, (2018)
  • [2] Hong I.K., Jeon H., Lee S.B., Extraction of natural dye from Gardenia and chromaticity analysis according to chi parameter, J Ind Eng Chem, 24, pp. 326-332, (2015)
  • [3] Wu S.Y., Wang G.F., Liu Z.Q., Rao J.J., Lu L., Xu W., Et al., Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin, Acta Pharmacol Sin, 30, 2, pp. 202-208, (2009)
  • [4] Lin W.H., Kuo H.H., Ho L.H., Tseng M.L., Siao A.C., Hung C.T., Jeng K.C., Hou C.W., Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells, Iran J Basic Med Sci, 18, 6, pp. 555-562, (2015)
  • [5] Liu D., Shu L., Anti-depressive activity of Gardeniae fructus and geniposide in mouse models of depression, Afr J Pharm Pharmacol, 5, 13, pp. 1580-1588, (2011)
  • [6] Debnath T., Park P.J., Deb Nath N.C., Samad N.B., Park H.W., Lim B.O., Antioxidant activity of Gardenia jasminoides Ellis fruit extracts, Food Chem, 128, 3, pp. 697-703, (2011)
  • [7] Kuratsune H., Umigai N., Takeno R., Kajimoto Y., Nakano T., Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study, Phytomedicine, 17, 11, pp. 840-843, (2010)
  • [8] Moras B., Loffredo L., Rey S., Quality assessment of saffron (Crocus sativus L.) extracts via UHPLC-DAD-MS analysis and detection of adulteration using gardenia fruit extract (Gardenia jasminoides Ellis), Food Chem, 257, pp. 325-332, (2018)
  • [9] Chen Y.I., Cheng Y.W., Tzeng C.Y., Lee Y.C., Chang Y.N., Lee S.C., Et al., Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats, BMC Complement Altern Med, 14, (2014)
  • [10] Tian J.S., Cui Y.L., Hu L.M., Gao S., Chi W., Dong T.J., Et al., Antidepressant-like effect of genipin in mice, Neurosci Lett, 479, 3, pp. 236-239, (2010)
123456789