Multicenter linkage study of schizophrenia loci on chromosome 22q

被引：0
作者：
B J Mowry
P A Holmans
A E Pulver
P V Gejman
B Riley
N M Williams
C Laurent
S G Schwab
D B Wildenauer
S Bauché
M J Owen
B Wormley
A R Sanders
G Nestadt
K Y Liang
J Duan
R Ribble
N Norton
S Soubigou
W Maier
K R Ewen-White
N deMarchi
B Carpenter
D Walsh
H Williams
M Jay
M Albus
D A Nertney
G Papadimitriou
A O'Neill
M C O'Donovan
J-F Deleuze
F B Lerer
D Dikeos
K S Kendler
J Mallet
J M Silverman
R R Crowe
D F Levinson
机构：
[1] Queensland Centre for Mental Health Research,Department of Psychiatry
[2] The Park – Centre for Mental Health,Department of Psychiatry
[3] University of Queensland,Department of Psychiatry
[4] MRC Biostatistics Unit,Department of Psychological Medicine
[5] Johns Hopkins University School of Medicine,Department of Psychiatry
[6] Northwestern University,Department of Biostatistics
[7] ENH Research Institute,Department of Psychiatry
[8] Virginia Institute for Psychiatric and Behavioral Genetics,Department of Psychiatry
[9] Virginia Commonwealth University,Department of Psychiatry
[10] University of Wales College of Medicine,Department of Psychiatry
[11] Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs,Mental Health Clinical Research Center and Department of Psychiatry
[12] Centre National de la Recherche Scientifique,Department of Psychiatry
[13] Hôpital de la Pitié Salpêtrière,undefined
[14] University of Bonn,undefined
[15] Johns Hopkins University Bloomberg School of Public Health,undefined
[16] Aventis Pharma SA,undefined
[17] Australian Genome Research Facility,undefined
[18] Walter and Eliza Hall Institute of Medical Research,undefined
[19] Parkville,undefined
[20] Clinica Psichiatrica,undefined
[21] Seconda Universita degli Studi di Napoli,undefined
[22] The Health Research Board,undefined
[23] State Mental Hospital,undefined
[24] University of Athens Medical School,undefined
[25] Queens University,undefined
[26] Hadassah-Hebrew University Medical Center,undefined
[27] Mt Sinai School of Medicine,undefined
[28] The University of Iowa College of Medicine,undefined
[29] University of Pennsylvania,undefined
来源：
Molecular Psychiatry | 2004年 / 9卷
关键词：
linkage (genetics); chromosomes, human, pair 22; schizophrenia; genetics, molecular; genetics, medical;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.
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页码：784 / 795
页数：11
相关论文
共 422 条
[1]  
Badner JA(2002)Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia Mol Psychiatry 7 405-411
[2]  
Gershon ES(2003)Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia Am J Hum Genet 73 34-48
[3]  
Lewis CM(1994)Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12–q13.1: part 1 Am J Med Genet 54 36-43
[4]  
Levinson DF(1995)Follow-up report of potential linkage for schizophrenia on chromosome 22q: part 3 Am J Med Genet 60 172-173
[5]  
Wise LH(1995)Linkage studies on chromosome 22 in familial schizophrenia Am J Med Genet 60 139-146
[6]  
DeLisi LE(1995)Potential linkage for schizophrenia on chromosome 22q12–q13: a replication study Am J Med Genet 60 436-443
[7]  
Straub RE(1995)Linkage analysis of chromosome 22q12–13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families Am J Med Genet 60 298-301
[8]  
Hovatta I(1996)No evidence for linkage of chromosome 22 markers to schizophrenia in southern African Bantu-speaking families Am J Med Genet 67 515-522
[9]  
Pulver AE(1997)No evidence for a schizophrenia susceptibility gene in the vicinity of IL2RB on chromosome 22 Am J Med Genet 74 361-364
[10]  
Karayiorgou M(1994)Analysis of chromosome 22 markers in nine schizophrenia pedigrees Am J Med Genet 15 72-79
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