Validation of computational fluid dynamics models for airway deposition with SPECT data of the same population

被引:7
作者
Sadafi, Hosein [1 ]
Tousi, Navid Monshi [1 ]
De Backer, Wilfried [1 ,2 ]
De Backer, Jan [3 ]
机构
[1] FLUIDDA NV, Groeningenlei 132, B-2550 Kontich, Belgium
[2] Univ Antwerp, Dept Resp Med, Antwerp, Belgium
[3] Fluidda Inc, 228 East 45th St,9th Floor,Suite 9E, New York, NY 10017 USA
关键词
CT; INHALER;
D O I
10.1038/s41598-024-56033-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study compared computational fluid dynamic (CFD) model predictions on aerosol deposition in six asthmatic patients to the in-vivo results of the same group. Patient-specific ventilation and internal air distribution were prescribed using inspiratory and expiratory CT scans of each patient, accounting for individual lobar air flow distribution. Moreover, the significant influence of realistic mouth and throat geometries on regional deposition is demonstrated. The in-vivo data were obtained from single photon emission computed tomography (SPECT) in 6 subjects with mild asthma selected from a database of historical clinical trials. The governing flow and particle tracking equations were solved numerically using a commercial CFD tool, and the modeled deposition results were compared to the SPECT data. Good agreement was found between the CFD model, applying k-omega SST turbulence model, and SPECT in terms of aerosol deposition. The average difference for the lobar deposition obtained from CFD model and SPECT/CT data was 2.1%. The high level of agreement is due to applying patient specific airway geometries and inspiratory/expiratory CT images, anatomical upper airways, and realistic airway trees. The results of this study show that CFD is a powerful tool to simulate patient-specific deposition if correct boundary conditions are applied and can generate similar information obtained with functional imaging tools, such as SPECT.
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页数:10
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