Hyperparasitaemia during clinical malaria episodes in infants aged 0-24 months and its association with in utero exposure to Plasmodium falciparum

被引：5
作者：
Sylvester B. [1 ]
Gasarasi D.B. [1 ]
Aboud S. [2 ]
Tarimo D. [1 ]
Massawe S. [3 ]
Mpembeni R. [4 ]
Swedberg G. [5 ]
机构：
[1] Department of Parasitology and Medical Entomology, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam
[2] Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam
[3] Department of Obstetrics and Gynaecology, School of Medicine, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam
[4] Department of Epidemiology and Biostatistics, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam
[5] Department of Medical Biochemistry and Microbiology, Biomedical Centre, Uppsala University, P.O.BOX 582, Uppsala
来源：
BMC Research Notes | / 11卷 / 1期
关键词：
Hyperparasitaemia; In utero; Infants; Malaria; P; falciparum; Parasite density;
D O I：
10.1186/s13104-018-3339-0
中图分类号：
学科分类号：
摘要：
Objective: Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This study is a component of a prospective cohort study for which initial results have been published. This component was designed to determine the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes in the first 24 months of life. A total of 215 infants were involved and monitored for clinical malaria episodes defined by fever (≥ 37 °C) and parasitaemia. The geometric mean parasite counts between exposed and unexposed infants were compared using independent samples t test. The effect of in utero exposure to P. falciparum on parasite density was assessed using binary logistic regression. Results: The geometric mean parasite count per μl of blood during clinical malaria episodes in exposed infants was 24,889 (95% CI 18,286-31,490) while in unexposed infants it was 14,035 (95% CI 12,111-15,960), P < 0.05. Prenatal exposure to P. falciparum was associated with hyperparasitaemia during clinical malaria episodes (OR 7.04, 95% CI 2.31-21.74), while other factors were not significantly associated (P > 0.05). © 2018 The Author(s).
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