MicroRNA Biomarkers for Coronary Artery Disease?

被引：0
作者：
Dorothee Kaudewitz
Anna Zampetaki
Manuel Mayr
机构：
[1] King’s College London,King’s British Heart Foundation Centre
来源：
Current Atherosclerosis Reports | 2015年 / 17卷
关键词：
MicroRNA; Biomarker; Coronary heart disease; Cardiovascular; Myocardial infarction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNA (miRNA, miR) measurements in patients with coronary heart disease are hampered by the confounding effects of medication commonly used in cardiovascular patients such as statins, antiplatelet drugs, and heparin administration. Statins reduce the circulating levels of liver-derived miR-122. Antiplatelet medication attenuates the release of platelet-derived miRNAs. Heparin inhibits the polymerase chain reactions, in particular the amplification of the exogenous Caenorhabditis elegans spike-in control, thereby resulting in an artefactual rise of endogenous miRNAs. As these limitations have not been previously recognised, a reevaluation of the current miRNA literature, in particular of case–control studies in patients with cardiovascular disease or coronary interventions, is required.
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[31]  
Fussell KC(2007)Redirection of silencing targets by adenosine-to-inosine editing of miRNAs Science 315 654-216
[32]  
Schneider S(2013)Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding Cell 153 209-208
[33]  
Wienholds E(2003)Functional siRNAs and miRNAs exhibit strand bias Cell 115 199-363
[34]  
Kloosterman WP(2003)Asymmetry in the assembly of the RNAi enzyme complex Cell 115 8-520
[35]  
Miska E(2012)MicroRNAs from the same precursor have different targeting properties Silence 3 354-798
[36]  
Alvarez-Saavedra E(2008)The regulatory activity of microRNA* species has substantial influence on microRNA and 3′ UTR evolution Nat Struct Mol Biol 15 513-840
[37]  
Berezikov E(2002)Prediction of plant microRNA targets Cell 110 787-16966
[38]  
de Bruijn E(2003)Prediction of mammalian microRNA targets Cell 115 835-680
[39]  
Cordes KR(2010)Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 16961-1934
[40]  
Srivastava D(2005)MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function Proc Natl Acad Sci U S A 102 671-2187
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