MicroRNA Biomarkers for Coronary Artery Disease?

被引：0
作者：
Dorothee Kaudewitz
Anna Zampetaki
Manuel Mayr
机构：
[1] King’s College London,King’s British Heart Foundation Centre
来源：
Current Atherosclerosis Reports | 2015年 / 17卷
关键词：
MicroRNA; Biomarker; Coronary heart disease; Cardiovascular; Myocardial infarction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNA (miRNA, miR) measurements in patients with coronary heart disease are hampered by the confounding effects of medication commonly used in cardiovascular patients such as statins, antiplatelet drugs, and heparin administration. Statins reduce the circulating levels of liver-derived miR-122. Antiplatelet medication attenuates the release of platelet-derived miRNAs. Heparin inhibits the polymerase chain reactions, in particular the amplification of the exogenous Caenorhabditis elegans spike-in control, thereby resulting in an artefactual rise of endogenous miRNAs. As these limitations have not been previously recognised, a reevaluation of the current miRNA literature, in particular of case–control studies in patients with cardiovascular disease or coronary interventions, is required.
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