Chemotherapy-Related Cognitive Dysfunction

被引：0
作者：
Jeffrey S. Wefel
Sanne B. Schagen
机构：
[1] MD Anderson Cancer Center,Department of Neuro
[2] Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital,Oncology
来源：
Current Neurology and Neuroscience Reports | 2012年 / 12卷
关键词：
Cognition; Chemotherapy; Neurotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many cancer patients develop treatment-related cognitive dysfunction that affects their quality of life and can result in diminished functional independence. There is an emerging body of transdisciplinary research demonstrating that chemotherapeutic agents can produce neurobiological changes within the brain, which are associated with a constellation of cognitive changes that can result in decreased quality of life and functional independence. The increased incidence of cancer, coupled with longer survival times, has resulted in larger numbers of cancer survivors who are struggling with this neurotoxicity. This review summarizes the neuropsychological findings in patients with breast and brain cancer who receive systemic chemotherapy as well as the recent animal and imaging research elucidating the mechanisms by which these therapies impact brain structure, function, and consequent behavior.
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页码：267 / 275
页数：8
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