PGC1α drives a metabolic block on prostate cancer progression

被引：0

作者：

Martina Wallace

Christian M. Metallo

机构：

[1] University of California,Martina Wallace and Christian M. Metallo are in the Department of Bioengineering

[2] San Diego,undefined

[3] La Jolla,undefined

[4] California,undefined

[5] USA.,undefined

[6] Christian M. Metallo is also at the Moores Cancer Center,undefined

[7] University of California,undefined

[8] San Diego,undefined

[9] La Jolla,undefined

[10] California,undefined

[11] USA.,undefined

来源：

Nature Cell Biology | 2016年 / 18卷

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D O I：

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学科分类号：

摘要：

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

引用

页码：589 / 590

页数：1

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