Autoimmune pancreatitis: An update on classification, diagnosis, natural history and management

被引：60
作者：
Raghuwansh P. Sah
Suresh T. Chari
机构：
[1] Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester
[2] Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905
来源：
Current Gastroenterology Reports | 2012年 / 14卷 / 2期
关键词：
Autoimmune pancreatitis; Chronic pancreatitis; Idiopathic duct centric pancreatitis; IgG4-related systemic disease; Lymphoplasmacytic sclerosing pancreatitis;
D O I：
10.1007/s11894-012-0246-8
中图分类号：
学科分类号：
摘要：
Autoimmune Pancreatitis (AIP) is a recently recognized chronic fibro-inflammatory disease of the pancreas. Although rare, its recognition continues to increase worldwide. Patients often present with painless obstructive jaundice mimicking pancreatic cancer. Two subtypes of AIP are known-type 1 is a multi-organ disease associated with IgG4; type 2 appears to be a pancreas-specific disorder. Dramatic response to steroid treatment is characteristic of both forms. A non-invasive diagnosis of type 1 AIP may be possible using diagnostic criteria (in ~70% cases) while diagnosis of type 2 requires histology. These subtypes differ in natural history- type 1 often relapses while initial reports suggest that type 2 does not. Long term complications include endocrine and exocrine insufficiency and in case of type 1, disease relapses and complications from extra-pancreatic involvement. Neither form affects long term survival. The treatment and follow-up guidelines continue to evolve with our increasing experience in AIP. © Springer Science+Business Media, LLC 2012.
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页码：95 / 105
页数：10
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