The efficacy of metformin in pregnant women with polycystic ovary syndrome: A meta-analysis of clinical trials

被引：0
作者：
J. Zheng
P. F. Shan
W. Gu
机构：
[1] the Second Affiliated Hospital ZheJiang University College of Medicine,Department of Endocrinology and Metabolism
[2] the Second Affiliated Hospital (Binjiang Branch) Zhejiang University College of Medicine,Department of Endocrinology and Metabolism
[3] Hangzhou Binjiang Hospital,undefined
来源：
Journal of Endocrinological Investigation | 2013年 / 36卷
关键词：
Metformin; pregnancy-related complications; polycystic ovary syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objectives: The role of metformin in the treatment of pregnant women with polycystic ovary syndrome (PCOS) is controversial. Therefore, we evaluated whether the use of metformin during pregnancy in women with PCOS could reduce pregnancy-related complications. Research design and methods: MEDLINE was searched to retrieve relevant trials. In addition, reviews and reference lists of the retrieved articles were scanned for further appropriate studies. The primary outcome measure was the incidence of complications of pregnancy, which included early pregnancy loss (EPL), gestational diabetes (GDM), pre-eclampsia (PE), and pre-term delivery (PD). Results: In total, eight studies with 1106 patients were included. The pooled odds ratio (OR) (95% confidence interval) of outcome for pregnant women with PCOS prescribed metformin were 0.32 (0.19–0.55) for EPL, 0.37 (0.25–0.56) for GDM, 0.53 (0.30–0.95) for PE and 0.30 (0.13–0.68) for PD. Conclusions: Metformin therapy throughout pregnancy decreased the OR of EPL, GDM, PE, and PD in pregnant PCOS women with no serious detrimental side effects.
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页码：797 / 802
页数：5
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