Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

被引：0
作者：
Igor Dzhura
Yuejin Wu
Roger J. Colbran
Jeffrey R. Balser
Mark E. Anderson
机构：
[1] Vanderbilt University,Department of Anesthesiology
[2] Vanderbilt University,Department of Internal Medicine
[3] Vanderbilt University,Department of Molecular Physiology and Biophysics
[4] Vanderbilt University,Department of Pharmacology
来源：
Nature Cell Biology | 2000年 / 2卷
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摘要：
A dynamic positive feedback mechanism, known as ‘facilitation’, augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are unknown. Here we show that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for ICa facilitation. CaMK induces a channel-gating mode that is characterized by frequent, long openings of L-type Ca2+ channels. We conclude that CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2+/CaM-dependent ICa facilitation.
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页码：173 / 177
页数：4
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