Intestinal stem cells

被引：224

作者：

Umar S. ^{[1
]}

机构：

[1] Department of Internal Medicine, Division of Digestive Diseases, University of Oklahoma Health Sciences Center, 975 NE 10th Street, SL Young BRC West 1268B, Oklahoma City, 73104, OK

来源：

Current Gastroenterology Reports | 2010年 / 12卷 / 5期

基金：

美国国家卫生研究院;

关键词：

Enterocytes; Enteroendocrine cells; Goblet cells; Inflammation; Intestinal crypts; Intestinal stem cell (ISC); Paneth cells; Radiation; Self-renewal; Transit amplifying (TA) cell;

D O I：

10.1007/s11894-010-0130-3

中图分类号：

学科分类号：

摘要：

Self-renewal in the intestinal epithelia is fueled by a population of undifferentiated intestinal stem cells (ISCs) that give rise to daughter or progenitor cells, which can subsequently differentiate into the mature cell types required for normal gut function. The cellular signals that regulate self-renewal are poorly understood and the factors that mediate the transition from a stem cell to a progenitor cell in the gut are unknown. Recent studies have suggested that ISCs are located either at the crypt base interspersed between the Paneth cells (eg, Lgr-5+ve cells) or at or near position 4 within the intestinal crypt (eg, DCAMKL-1 or Bmi-1+ve cells). This raises the possibility that distinct stem cell regions exist in the crypts and that ISC's state of activation will determine how the self-renewal is regulated in the intestinal tract. © 2010 Springer Science+Business Media, LLC.

引用

页码：340 / 348

页数：8

共 68 条

[41]

musashi-1, Differentiation, 71, 1, pp. 28-41, (2003)

[42]

Tian Q., Feetham M.C., Tao W.A., He X.C., Li L., Aebersold R., Hood L., Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt, Proceedings of the National Academy of Sciences of the United States of America, 101, 43, pp. 15370-15375, (2004)

[43]

Dekaney C.M., Rodriguez J.M., Graul M.C., Henning S.J., Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum, Gastroenterology, 129, 5, pp. 1567-1580, (2005)

[44]

Gulati A.S., Ochsner S.A., Henning S.J., Molecular properties on side population-sorted cells from mouse small intestine, Am J Physiol Gastrointest Liver Physiol, 294, (2008)

[45]

Vidrich A., Buzan J.M., Ilo C., Bradley L., Skaar K., Cohn S.M., Fibroblast Growth Factor Receptor-3 Is Expressed in Undifferentiated Intestinal Epithelial Cells during Murine Crypt Morphogenesis, Developmental Dynamics, 230, 1, pp. 114-123, (2004)

[46]

Blache P., Van De Wetering M., Duluc I., Domon C., Berta P., Freund J.-N., Clevers H., Jay P., SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, Journal of Cell Biology, 166, 1, pp. 37-47, (2004)

[47]

Van Der Flier L.G., Sabates-Bellver J., Oving I., Et al., The intestinal Wnt/TCF signature, Gastroenterology, 132, pp. 628-632, (2007)

[48]

Breault D.T., Min I.M., Carlone D.L., Et al., Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells, Proc Natl Acad Sci U S A, 105, pp. 10420-10425, (2008)

[49]

Stappenbeck T.S., Mills J.C., Gordon J.I., Molecular features of adult mouse small intestinal epithelial progenitors, Proceedings of the National Academy of Sciences of the United States of America, 100, 3, pp. 1004-1009, (2003)

[50]

Giannakis M., Stappenbeck T.S., Mills J.C., Leip D.G., Lovett M., Clifton S.W., Ippolito J.E., Glasscock J.I., Arumugam M., Brent M.R., Gordon J.I., Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches, Journal of Biological Chemistry, 281, 16, pp. 11292-11300, (2006)

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