Antimicrobial Resistance of Escherichia coli Causing Uncomplicated Urinary Tract Infections: A European Update for 2014 and Comparison with 2000 and 2008

被引：63

作者：

Kahlmeter G. ^{[1
]}

Åhman J. ^{[1
]}

Matuschek E. ^{[1
]}

机构：

[1] Department of Clinical Microbiology, Central Hospital, Växjö

来源：

Infectious Diseases and Therapy | 2015年 / 4卷 / 4期

关键词：

Amoxicillin–clavulanic acid; Antimicrobial resistance; Cefadroxil; Ciprofloxacin; Escherichia coli; Mecillinam; Nitrofurantoin; Susceptibility; Trimethoprim; Urinary isolates; Urinary tract infections;

D O I：

10.1007/s40121-015-0095-5

中图分类号：

学科分类号：

摘要：

Introduction: The objective of this study was to provide an update on the resistance of Escherichia coli in women with acute uncomplicated urinary tract infections (UTIs) in France, Germany, Spain, Sweden, and the United Kingdom (UK) to mecillinam [amdinocillin (United States Adopted Name)], amoxicillin–clavulanic acid, cefadroxil, nitrofurantoin, ciprofloxacin, and trimethoprim, and to compare the results with resistance in the ECO.SENS I and II surveys in 2000 and 2008, respectively. Methods: The susceptibility of E. coli in France (166 isolates), Germany (133 isolates), Spain (169 isolates), Sweden (137 isolates), and the UK (124 isolates) was determined by disc diffusion according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints and methodology. Resistance rates were compared using Fisher’s exact test, 2-tailed, with P < 0.05 indicating statistical significance. Results: Since 2000, there has been a significant increase in resistance to cefadroxil in Germany (1% to 12%) and Spain (3% to 8%), to ciprofloxacin in Germany (2% to 21%), Spain (15% to 31%), Sweden (0% to 7%), and the UK (1% to 15%), to trimethoprim in Germany (23% to 37%), Spain (25% to 37%), Sweden (9% to 17%), and the UK (13% to 46%), to mecillinam in Spain (1% to 6.5%), and to nitrofurantoin in the UK (0% to 6%); there was also a significant decrease in resistance to nitrofurantoin in Spain (4% to 0%). Since 2008, there has been a significant increase in resistance to ciprofloxacin in Sweden (3% to 15%) and the UK (1% to 15%), and to trimethoprim (13% to 46%) and nitrofurantoin (0% to 6%) in the UK. Conclusion: E. coli isolates from women with acute uncomplicated UTIs have increasing antimicrobial resistance, particularly to ciprofloxacin and trimethoprim. However, resistance to mecillinam and nitrofurantoin mostly remains low. Funding: LEO Pharma. © 2015, The Author(s).

引用

页码：417 / 423

页数：6

共 16 条

[1]

Allocati N., Masulli M., Alexeyev M.F., Di Ilio C., Escherichia coli in Europe: an overview, Int J Environ Res Public Health, 10, pp. 6235-6254, (2013)

[2]

Kahlmeter G., An international survey of the antimicrobial susceptibility of pathogens from acute uncomplicated urinary tract infections: the ECO.SENS project, J Antimicrob Chemothe, 51, pp. 69-76, (2003)

[3]

Kahlmeter G., Poulsen H.O., Antimicrobial susceptibility of Escherichia coli from community-acquired urinary tract infections in Europe: the ECO.SENS study revisited, Int J Antimicrob Agent, 39, pp. 45-51, (2012)

[4]

EUCAST Disk Diffusion Test Manua, 4, (2014)

[5]

Breakpoint tables for interpretation of MICs and zone diameters, Versio, 4, (2014)

[6]

Lobet B., Valot A., Cattoir V., Et al., Comparison of antimicrobial susceptibility of 1217 Escherichia coli isolates from women with hospital and community acquired urinary tract infections (Article in French), Presse Me, 37, pp. 46-50, (2008)

[7]

Neuzillet V., Naber K.G., Schito G., Et al., French results of the ARESC study: clinical aspects and epidemiology of antimicrobial resistance in female patients with cystitis. Implications for therapy, Med Mal Infect, 42, pp. 66-75, (2012)

[8]

Kresken M., Pfeifer Y., Hafner D., Et al., Occurrence of multidrug resistance to oral antibiotics among Escherichia coli urine isolates from outpatient departments in Germany: extended-spectrum beta-lactamases and the role of fosfomycin, Int J Antimicrob Agent, 44, pp. 295-300, (2014)

[9]

Schmiemann G., Gagyor I., Hummers-Pradier E., Resistance profiles of urinary tract pathogens in general practice—an observational study, BMC Uro, pp. 21-33, (2012)

[10]

Garcia Garcia M.L., Munoz Bellido J.L., Garcia Rodriguez J.A., Et al., In vitro susceptibility of community-acquired urinary tract pathogens to commonly used antimicrobial agents in Spain: a comparative multicenter study (2002–2004), J Chemothe, 19, pp. 263-270, (2007)

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