Incidence of Herb-Induced Aconitine Poisoning in Hong KongImpact of Publicity Measures to Promote Awareness Among the Herbalists and the Public

被引:0
作者
Thomas Y. K. Chan
机构
[1] The Chinese University of Hong Kong,Division of Clinical Pharmacology, Department of Medicine and Therapeutics
[2] Prince of Wales Hospital,undefined
[3] Shatin,undefined
[4] New Territories,undefined
来源
Drug Safety | 2002年 / 25卷
关键词
Root Tuber; Aconitine; Aconite; Wale Hospital; Herbal Decoction;
D O I
暂无
中图分类号
学科分类号
摘要
Background: In Hong Kong ‘chuanwu’ (the main root of Aconitum carmichaeli) and ‘caowu’ (the root of Aconitum kusnezoffii) are used by herbalists to treat patients with various musculoskeletal disorders. These aconite roots contain aconitine, mesaconitine and hypaconitine, which are neurotoxins and cardiotoxins. During 1989 to 1991, 31 patients were treated in public hospitals because of poisoning by aconite roots and there were two deaths from ventricular arrhythmias. In late 1991, healthcare officials together with cardiologists held a press conference to warn the public, healthcare professionals and herbalists of the potential toxicity of aconite roots. The risk of ventricular arrhythmias and the need for urgent medical attention were highlighted. An information leaflet was also sent to hospital doctors. Since 1992, the topic was covered periodically in the local newspapers, medical journals and continuing medical education programmes.
引用
收藏
页码:823 / 828
页数:5
相关论文
共 21 条
[1]  
Chan TYK(1994)Aconitine poisoning: a global perspective Hum Exp Toxicol 36 326-8
[2]  
Catterall WA(1980)Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes Annu Rev Pharmacol Toxicol 2 15-43
[3]  
Chan TYK(1994)Aconitine poisoning due to Chinese herbal medicines: a review Vet Hum Toxicol 36 452-5
[4]  
Tomlinson B(1992)Cardiotoxicity after accidental herb-induced aconite poisoning Lancet 340 1254-6
[5]  
Tse LKK(1981)Arrow poisonings in China. Part II. Aconitum -botany, chemistry and pharmacology J Ethnopharmacol 4 247-336
[6]  
Tai YT(1993)Determination of aconitine in wutou and related herbal drugs (roots of Aconitum) and their processed products in Hong Kong market [in Chinese] Chung-Kuo Chung Yao Tsa Chih 18 279-81
[7]  
But PPH(1997)Monitoring the safety of herbal medicines Drug Saf 17 209-15
[8]  
Young K(1995)Computer-assisted pharmacovigilance in hospitalized patients [letter] Ann Pharmacother 29 788-9
[9]  
Bisset NG(1995)Role of the Drug and Poisons Information Bureau in monitoring the safety of Chinese herbal medicines in Hong Kong J Nat Toxins 4 203-6
[10]  
Cao H(1994)Poisoning by Chinese medicines in Hong Kong: a hospital-based study Vet Hum Toxicol 36 546-7