Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives

被引：0
作者：
Mohamed T. Abdel-Aal
Abdel-Aleem H. Abdel-Aleem
Laila I. Ibahim
Ahmed L. Zein
机构：
[1] Menofeia University,Department of Chemistry, Faculty of Science
[2] National Organization of Drug Control and Research,undefined
来源：
Archives of Pharmacal Research | 2010年 / 33卷
关键词：
Aroylhydrazones; 5-Amino-4-cyanopyrazole; Quinazoline-4-one; Antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
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页码：1891 / 1900
页数：9
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