Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss

被引：0
|
作者：
Pablo César Ortiz-Lazareno
Alejandro Bravo-Cuellar
José Manuel Lerma-Díaz
Luis Felipe Jave-Suárez
Adriana Aguilar-Lemarroy
Jorge Ramiro Domínguez-Rodríguez
Oscar González-Ramella
Ruth De Célis
Paulina Gómez-Lomelí
Georgina Hernández-Flores
机构：
[1] Instituto Mexicano del Seguro Social (IMSS),División de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO)
[2] Universidad de Guadalajara (UdeG),Centro Universitario de los Altos
[3] Centro Universitario de Ciencias Exactas e Ingeniería,Departamento de Farmacobiología
[4] OPD Hospital Civil Juan I. Menchaca,Servicio de Hemato
[5] Programa de Doctorado en Ciencias Biomédicas Orientación Inmunología,Oncología Pediatría
[6] Centro Universitario de Ciencias de la Salud,undefined
来源：
Cancer Cell International | / 14卷
关键词：
Apoptosis; NF-кB; Caspase activation; Mitochondrial dysfunction; Senescence; MG132; Doxorubicin; Leukemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 13 条
  • [1] Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
    Cesar Ortiz-Lazareno, Pablo
    Bravo-Cuellar, Alejandro
    Manuel Lerma-Diaz, Jose
    Felipe Jave-Suarez, Luis
    Aguilar-Lemarroy, Adriana
    Ramiro Dominguez-Rodriguez, Jorge
    Gonzalez-Ramella, Oscar
    De Cellis, Ruth
    Gomez-Lomeli, Paulina
    Hernandez-Flores, Georgina
    CANCER CELL INTERNATIONAL, 2014, 14
  • [2] Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells
    Lee, Han Ki
    Park, See-Hyoung
    Nam, Myeong Jin
    HUMAN & EXPERIMENTAL TOXICOLOGY, 2021, 40 (11) : 1985 - 1997
  • [3] Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65
    Bravo-Cuellar, Alejandro
    Hernandez-Flores, Georgina
    Manuel Lerma-Diaz, Jose
    Ramiro Dominguez-Rodriguez, Jorge
    Jave-Suarez, Luis F.
    De Celis-Carrillo, Ruth
    Aguilar-Lemarroy, Adriana
    Gomez-Lomeli, Paulina
    Cesar Ortiz-Lazareno, Pablo
    JOURNAL OF BIOMEDICAL SCIENCE, 2013, 20
  • [4] Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65
    Alejandro Bravo-Cuellar
    Georgina Hernández-Flores
    José Manuel Lerma-Díaz
    Jorge Ramiro Domínguez-Rodríguez
    Luis F Jave-Suárez
    Ruth De Célis-Carrillo
    Adriana Aguilar-Lemarroy
    Paulina Gómez-Lomeli
    Pablo Cesar Ortiz-Lazareno
    Journal of Biomedical Science, 20
  • [5] Synergism between arsenite and proteasome inhibitor MG132 over cell death in myeloid leukaemic cells U937 and the induction of low levels of intracellular superoxide anion
    Lombardo, Tomas
    Cavaliere, Victoria
    Costantino, Susana N.
    Kornblihtt, Laura
    Alvarez, Elida M.
    Blanco, Guillermo A.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 258 (03) : 351 - 366
  • [6] The Proteasome Inhibitor MG132 Sensitizes Lung Cancer Cells to TRAIL-induced Apoptosis by Inhibiting NF-k B Activation
    Seo, Pil Won
    Lee, Kye Young
    TUBERCULOSIS AND RESPIRATORY DISEASES, 2008, 65 (06) : 476 - 486
  • [7] The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
    Decker, RH
    Dai, Y
    Grant, S
    CELL DEATH AND DIFFERENTIATION, 2001, 8 (07) : 715 - 724
  • [8] The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
    R H Decker
    Y Dai
    S Grant
    Cell Death & Differentiation, 2001, 8 : 715 - 724
  • [9] Pseudolaric acid B induces apoptosis in U937 human leukemia cells via caspase-9-mediated activation of the mitochondrial death pathway
    Wang, Jia-He
    Kan, Liang
    Shu, Lin-Hua
    Wang, Nan
    Li, Nai-Jing
    Zhang, Meng
    MOLECULAR MEDICINE REPORTS, 2013, 8 (03) : 787 - 793
  • [10] Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
    Alfeu Zanotto-Filho
    Elizandra Braganhol
    Ana Maria Oliveira Battastini
    José Cláudio Fonseca Moreira
    Investigational New Drugs, 2012, 30 : 2252 - 2262
12