A novel CDK4/6 inhibitor combined with irradiation demonstrates potent anti-tumor efficacy in diffuse midline glioma

Vanan MI(2015)DIPG in children—what can we learn from the past? Front Oncol 5 237-25

Eisenstat DD(2019)Preclinical therapeutic targets in diffuse midline glioma Drug Resist Updates 44 15-4784

Meel MH(2001)Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo Mol Cell Biol 21 4773-475

Kaspers GJL(2017)CDK4/6 inhibition triggers anti-tumour immunity Nature 548 471-537e525

Hulleman E(2017)Integrated molecular meta-analysis of 1000 pediatric high-grade and diffuse intrinsic pontine glioma Cancer Cell 32 520-3500

Ezhevsky SA(2018)Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity Cancer Manage Res 10 3483-24

Ho A(2013)PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma PLoS ONE 8 e77639-179

Becker-Hapak M(2019)Authors' reply to “Translating palbociclib to the clinic for DIPG—what is truly achievable?” EBioMedicine 45 23-1438

Davis PK(2019)Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma EBioMedicine 43 171-5657

Dowdy SF(2004)Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Mol Cancer Ther 3 1427-829

Vanan MI(2015)DIPG in children—what can we learn from the past? Front Oncol 5 237-25

Eisenstat DD(2019)Preclinical therapeutic targets in diffuse midline glioma Drug Resist Updates 44 15-4784

Meel MH(2001)Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo Mol Cell Biol 21 4773-475

Kaspers GJL(2017)CDK4/6 inhibition triggers anti-tumour immunity Nature 548 471-537e525

Hulleman E(2017)Integrated molecular meta-analysis of 1000 pediatric high-grade and diffuse intrinsic pontine glioma Cancer Cell 32 520-3500

Ezhevsky SA(2018)Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity Cancer Manage Res 10 3483-24

Ho A(2013)PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma PLoS ONE 8 e77639-179

Becker-Hapak M(2019)Authors' reply to “Translating palbociclib to the clinic for DIPG—what is truly achievable?” EBioMedicine 45 23-1438

Davis PK(2019)Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma EBioMedicine 43 171-5657

Dowdy SF(2004)Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Mol Cancer Ther 3 1427-829