Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes

被引:0
|
作者
Ulf Hannelius
Craig A. Beam
Johnny Ludvigsson
机构
[1] Diamyd Medical AB,Department of Biomedical Sciences
[2] Western Michigan University Homer Stryker M.D. School of Medicine,Division of Pediatrics, Department of Biomedical and Clinical Sciences (BKV), Medical Faculty
[3] Crown Princess Victoria Children’s Hospital,undefined
[4] Linköping University,undefined
来源
Diabetologia | 2020年 / 63卷
关键词
Antigen-specific; Autoimmune diabetes; C-peptide; GAD; Glutamic acid decarboxylase; HLA; Immunotherapy; Type 1 diabetes; Vaccine;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2177 / 2181
页数:4
相关论文
共 49 条
  • [11] HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD
    Fukui, M
    Nakamura, N
    Nakano, K
    Kajiyama, S
    Matsuo, S
    Obayashi, H
    Ohta, M
    Shigeta, M
    Shigeta, H
    Kitagawa, Y
    Kondo, M
    ENDOCRINE JOURNAL, 2000, 47 (06) : 753 - 761
  • [12] Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes
    Redondo, Maria J.
    Cuthbertson, David
    Steck, Andrea K.
    Herold, Kevan C.
    Oram, Richard
    Atkinson, Mark
    Brusko, Todd M.
    Parikh, Hemang M.
    Krischer, Jeffrey P.
    Onengut-Gumuscu, Suna
    Rich, Stephen S.
    Sosenko, Jay M.
    DIABETOLOGIA, 2025, 68 (03) : 588 - 601
  • [13] Immune response differs between intralymphatic or subcutaneous administration of GAD-alum in individuals with recent onset type 1 diabetes
    Dietrich, Fabricia
    Barcenilla, Hugo
    Tavira, Beatriz
    Wahlberg, Jeanette
    Achenbach, Peter
    Ludvigsson, Johnny
    Casas, Rosaura
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2022, 38 (03)
  • [14] GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
    Hjorth, Maria
    Axelsson, Stina
    Ryden, Anna
    Faresjo, Maria
    Ludvigsson, Johnny
    Casas, Rosaura
    CLINICAL IMMUNOLOGY, 2011, 138 (01) : 117 - 126
  • [15] GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus
    Ludvigsson, Johnny
    Krisky, David
    Casas, Rosaura
    Battelino, Tadej
    Castano, Luis
    Greening, James
    Kordonouri, Olga
    Otonkoski, Timo
    Pozzilli, Paolo
    Robert, Jean-Jacques
    Veeze, Henk J.
    Palmer, Jerry
    NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (05) : 433 - 442
  • [16] Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adults
    Törn, C
    Gupta, M
    Zake, LN
    Sanjeevi, CB
    Landin-Olsson, M
    HUMAN IMMUNOLOGY, 2003, 64 (09) : 902 - 909
  • [17] HLA-DR, DQ and anti-GAD antibodies in first degree relatives of Type I diabetes mellitus
    SerranoRios, M
    Lopez, MDG
    PerezBravo, F
    Martinez, MT
    Antona, J
    Rowley, M
    Mackay, I
    Zimmet, P
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1996, 34 : S133 - S139
  • [18] Genomic evaluation of HLA-DR3+ haplotypes associated with type 1 diabetes
    Kumar, Neeraj
    Kaur, Gurvinder
    Tandon, Nikhil
    Kanga, Uma
    Mehra, Narinder
    TRANSLATIONAL IMMUNOLOGY IN ASIA-OCEANIA, 2013, 1283 : 91 - 96
  • [19] GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis
    Beam, Craig A.
    MacCallum, Colleen
    Herold, Kevan C.
    Wherrett, Diane K.
    Palmer, Jerry
    Ludvigsson, Johnny
    DIABETOLOGIA, 2017, 60 (01) : 43 - 49
  • [20] Changing profile of GAD and IA-2 antibody positivity in Indian children with recently diagnosed type 1 diabetes mellitus
    Sanyal, Debmalya
    Batabyal, Sandip K.
    Maity, Subrata
    Chatterjee, Sudip
    CLINICAL DIABETOLOGY, 2019, 8 (02): : 116 - 120