The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe

被引：0

作者：

Nadia Haddy

Dirk De Bacquer

Marianne Mansour Chemaly

Mickaël Maurice

Christian Ehnholm

Alun Evans

Susanna Sans

Maria do Carmo Martins

Guy De Backer

Gérard Siest

Sophia Visvikis

机构：

[1] INSERM U 525 Equipe 4,Department of Public Health

[2] University of Gent,Department of Biochemistry

[3] National Public Health Institute,Department of Epidemiology and Public Health

[4] Queen's University,undefined

[5] Programa Cronicat,undefined

[6] Instituto National de Saude,undefined

[7] Unidade de Quimica Clinica,undefined

[8] Instituto National de Saude,undefined

来源：

European Journal of Human Genetics | 2002年 / 10卷

关键词：

cardiovascular risk; ApoEurope; apoE polymorphism; apoE concentration; inter-individual lipid levels variation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the ε2 allele frequency and the apoE concentration showed a north–south increasing gradient while the ε4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.

引用

页码：841 / 850

页数：9

共 117 条

[21]

Vincent-Viry M(1986)A rapid apolipoprotein E radioimmunoassay using solid-phase staphylococcus protein. Use of pooled plasma as a secondary standard Biochem Biophys Res Commun 138 455-167

[22]

Ehnholm C(1992)Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world Genet Epidemiol 9 155-335

[23]

Lukka M(2000)Association of apolipoprotein (Apo)E genotype with plasma apo E levels Atherosclerosis 148 327-176

[24]

Kuusi T(1999)Apolipoprotein E polymorphism in men and women from a Spanish population: allele frequencies and influence on plasma lipids and apolipoproteins Atherosclerosis 147 167-186

[25]

Nikkila E(1991)Impact of apo E phenotype on the regulation of cholesterol metabolism Ann Med 23 181-1324

[26]

Utermann G(1996)Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors J Lipid Res 37 1316-E557

[27]

Wilson PW(1999)Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes Am J Physiol 276 E553-19057

[28]

Schaefer EJ(1996)Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins J Biol Chem 271 19053-285

[29]

Larson MG(1985)Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation Am J Hum Genet 37 268-730

[30]

Ordovas JM(2000)Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group Clin Chem Lab Med 38 721-659

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