The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe

被引：0
作者：
Nadia Haddy
Dirk De Bacquer
Marianne Mansour Chemaly
Mickaël Maurice
Christian Ehnholm
Alun Evans
Susanna Sans
Maria do Carmo Martins
Guy De Backer
Gérard Siest
Sophia Visvikis
机构：
[1] INSERM U 525 Equipe 4,Department of Public Health
[2] University of Gent,Department of Biochemistry
[3] National Public Health Institute,Department of Epidemiology and Public Health
[4] Queen's University,undefined
[5] Programa Cronicat,undefined
[6] Instituto National de Saude,undefined
[7] Unidade de Quimica Clinica,undefined
[8] Instituto National de Saude,undefined
来源：
European Journal of Human Genetics | 2002年 / 10卷
关键词：
cardiovascular risk; ApoEurope; apoE polymorphism; apoE concentration; inter-individual lipid levels variation;
D O I：
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中图分类号：
学科分类号：
摘要：
Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the ε2 allele frequency and the apoE concentration showed a north–south increasing gradient while the ε4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.
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页码：841 / 850
页数：9
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