Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids

被引：0
|
作者：
E. V. Verves
A. V. Kucher
L. V. Muzychka
O. B. Smolii
机构：
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
来源：
Chemistry of Heterocyclic Compounds | 2013年 / 48卷
关键词：
ethyl ; -alkylglycinate; pyrimido[5',4':4,5]pyrrolo[2,1-; ][1,4]oxazine; 7; -pyrrolo[2,3-; ]-pyrimidine; cyclization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two variants are discussed for the synthesis of ethyl N-alkyl-N-(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido- [5',4':4,5]pyrrolo[2,1-c][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.
引用
收藏
页码：1844 / 1852
页数：8
相关论文
共 50 条
  • [21] Reaction of 2-alkylthio-6-amino-pyrimidin-4(3H)-ones with ethyl bromopyruvate. Synthesis of furo-[2,3-d]-pyrimidine and furo[3,2-e]imidazo-[1,2-c]pyrimidine carboxylates
    Masevicius, V.
    Petraityte, G.
    Tumkevicius, S.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (03) : 357 - 360
  • [22] A novel and efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione and pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives
    Dabiri, Minoo
    Arvin-Nezhad, Harnid
    Khavasi, Hamid Reza
    Bazgir, Ayoob
    TETRAHEDRON, 2007, 63 (08) : 1770 - 1774
  • [23] Synthesis of 8-Aryl-substituted-4-amino-6-chloro-8H-pteridin-7-one
    Duan, Chong-Gang
    Xu, Wei-Ren
    Tang, Li-Da
    Jia, Jiong
    Wang, Jian-Wu
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2008, 28 (10) : 1830 - 1835
  • [24] Synthesis of 6-substituted 5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4-diones and 2-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-ones
    Aksinenko, A. Yu.
    Sokolov, V. B.
    Goreva, T. V.
    Epishina, T. A.
    Pushin, A. N.
    RUSSIAN CHEMICAL BULLETIN, 2008, 57 (07) : 1543 - 1546
  • [25] Microwave Assisted Synthesis of 2,3-Dihydro-4H- furo[2,3-d]pyrido[1,2-a]pyrimidin-4-ones and furo[2,3-d]pyrido[1,2-a]pyrimidin-4-one
    Yalduz, Sumeyye
    Yilmaz, Mehmet
    CHEMISTRYSELECT, 2023, 8 (10):
  • [26] Synthesis of 6-substituted 5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4-diones and 2-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-ones
    A. Yu. Aksinenko
    V. B. Sokolov
    T. V. Goreva
    T. A. Epishina
    A. N. Pushin
    Russian Chemical Bulletin, 2008, 57 : 1543 - 1546
  • [27] Synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetra- hydropyrido[3,4-d]pyrimidine
    Kuznetsov A.Yu.
    Chapyshev S.V.
    Chemistry of Heterocyclic Compounds, 2007, 43 (10) : 1320 - 1324
  • [28] A new route to the synthesis of 4-amino-substituted pyrido[2,3-d]pyrimidin-5-one derivatives
    Komkov, A. V.
    Baranin, S. V.
    Dmitrenok, A. S.
    Kolotyrkina, N. G.
    Zavarzin, I. V.
    RUSSIAN CHEMICAL BULLETIN, 2021, 70 (02) : 378 - 382
  • [29] A new route to the synthesis of 4-amino-substituted pyrido[2,3-d]pyrimidin-5-one derivatives
    Komkov A.V.
    Baranin S.V.
    Dmitrenok A.S.
    Kolotyrkina N.G.
    Zavarzin I.V.
    Russian Chemical Bulletin, 2021, 70 (2) : 378 - 382
  • [30] One-pot synthesis of 4-aminated pyrrolo[2,3-d]pyrimidines from alkynylpyrimidines under metal-catalyst-free conditions
    Prieur, Vanessa
    Heindler, Nina
    Rubio-Martinez, Jaime
    Guillaumet, Gerald
    Dolors Pujol, M.
    TETRAHEDRON, 2015, 71 (08) : 1207 - 1214
12345