Denaturation and Aggregation of Interferon-τ in Aqueous Solution

[1] Chon TW(2010)Interferon-t: current applications and potential in antiviral therapy J Interferon Cytokine Res 30 477-485

[2] Bixler S(1999)Crystal structure of ovine interferon-tau at 2.1 a resolution J Mol Biol 286 151-162

[3] Radhakrishnan R(2003)Physical stability of proteins in aqeuous solutions: mechanism and driving forces in nonnative protein aggregation Pharm Res 20 1325-1332

[4] Walter LJ(2010)Stability of protein pharmaceuticals: an update Pharm Res 27 544-575

[5] Subramaniam PS(2013)Chemical denaturation as a tool in the formulation optimization of biologics Drug Discov Today 18 1007-1013

[6] Johnson HM(2005)Solution of a novel type 1 interferon, interferon-t J Pharm Sci 94 2703-2715

[7] Walter MR(2006)Effect of buffer species on the thermally induced aggregation of interferon-tau J Pharm Sci 95 1212-1226

[8] Chi EY(1994)Protien denaturation with guanidine hydrochloride or urea provides a different estimate of stability depanding on the contributions of electrostatic interactions Protein Sci 3 1984-1991

[9] Krishnan S(1996)Guanidine hydrochloride unfolding of peptide helices: separation of denaturant and salt effects Biochemistry 35 7292-7297

[10] Randolph TW(1974)Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, a-chymotrypsin, and b-lactoglobulin J Biol Chem 249 5388-5393

[1] Chon TW(2010)Interferon-t: current applications and potential in antiviral therapy J Interferon Cytokine Res 30 477-485

[2] Bixler S(1999)Crystal structure of ovine interferon-tau at 2.1 a resolution J Mol Biol 286 151-162

[3] Radhakrishnan R(2003)Physical stability of proteins in aqeuous solutions: mechanism and driving forces in nonnative protein aggregation Pharm Res 20 1325-1332

[4] Walter LJ(2010)Stability of protein pharmaceuticals: an update Pharm Res 27 544-575

[5] Subramaniam PS(2013)Chemical denaturation as a tool in the formulation optimization of biologics Drug Discov Today 18 1007-1013

[6] Johnson HM(2005)Solution of a novel type 1 interferon, interferon-t J Pharm Sci 94 2703-2715

[7] Walter MR(2006)Effect of buffer species on the thermally induced aggregation of interferon-tau J Pharm Sci 95 1212-1226

[8] Chi EY(1994)Protien denaturation with guanidine hydrochloride or urea provides a different estimate of stability depanding on the contributions of electrostatic interactions Protein Sci 3 1984-1991

[9] Krishnan S(1996)Guanidine hydrochloride unfolding of peptide helices: separation of denaturant and salt effects Biochemistry 35 7292-7297

[10] Randolph TW(1974)Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, a-chymotrypsin, and b-lactoglobulin J Biol Chem 249 5388-5393