Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

被引：0

作者：

Anubha Mahajan

Min Jin Go

Weihua Zhang

Jennifer E Below

Kyle J Gaulton

Teresa Ferreira

Momoko Horikoshi

Andrew D Johnson

Maggie C Y Ng

Inga Prokopenko

Danish Saleheen

Xu Wang

Eleftheria Zeggini

Goncalo R Abecasis

Linda S Adair

Peter Almgren

Mustafa Atalay

Tin Aung

Damiano Baldassarre

Beverley Balkau

Yuqian Bao

Anthony H Barnett

Ines Barroso

Abdul Basit

Latonya F Been

John Beilby

Graeme I Bell

Rafn Benediktsson

Richard N Bergman

Bernhard O Boehm

Eric Boerwinkle

Lori L Bonnycastle

Noël Burtt

Qiuyin Cai

Harry Campbell

Jason Carey

Stephane Cauchi

Mark Caulfield

Juliana C N Chan

Li-Ching Chang

Tien-Jyun Chang

Yi-Cheng Chang

Guillaume Charpentier

Chien-Hsiun Chen

Han Chen

Yuan-Tsong Chen

Kee-Seng Chia

Manickam Chidambaram

Peter S Chines

Nam H Cho

机构：

[1] Wellcome Trust Centre for Human Genetics,Department of Genome Sciences

[2] University of Oxford,Department of Public Health and Primary Care

[3] Center for Genome Science,Department of Epidemiology and Public Health

[4] National Institute of Health,Department of Biostatistics

[5] Osong Health Technology Administration Complex,Department of Nutrition

[6] Chungcheongbuk-do,Department of Clinical Science Malmö

[7] Cheongwon-gun,Department of Ophthalmology

[8] Gangoe-myeon,Department of Pharmacological Sciences

[9] Epidemiology and Biostatistics,Department of Endocrinology and Metabolism

[10] Imperial College London,Department of Pediatrics

[11] University of Washington,Department of Medicine

[12] Oxford Centre for Diabetes,Department of Human Genetics

[13] Endocrinology and Metabolism,Department of Internal Medicine, Division of Endocrinology and Diabetes

[14] University of Oxford,Department of Medicine

[15] National Heart,Department of Medicine and Therapeutics

[16] Lung and Blood Institute's Framingham Heart Study,Department of Internal Medicine

[17] Center for Genomics and Personalized Medicine Research,Department of Biostatistics

[18] Wake Forest School of Medicine,Department of Molecular Genetics

[19] Center for Diabetes Research,Department of Preventive Medicine

[20] Wake Forest School of Medicine,Department of Internal Medicine

[21] Genomics of Common Disease,Department of Nutrition and Epidemiology

[22] Imperial College London,Department of Biostatistics

[23] Hammersmith Hospital,Division of Cardiovascular Epidemiology

[24] University of Cambridge,Department of Dietetics

[25] Center for Non-Communicable Diseases Pakistan,Nutrition

[26] National University of Singapore,Department of Genetic Medicine and Development

[27] Wellcome Trust Sanger Institute,Department of Statistics

[28] Hinxton,Department of Epidemiology

[29] University of Michigan,Department of Chronic Disease Prevention

[30] University of North Carolina,Department of General Practice and Primary Health Care

[31] Lund University Diabetes Centre,Division of Genetics and Endocrinology

[32] Scania University Hospital,Department of Medicine

[33] Lund University,Division of Endocrinology and Metabolism

[34] Institute of Biomedicine,Department of Epidemiology

[35] University of Eastern Finland,Department of Medicine Solna

[36] Kuopio Campus,Department of Twin Research and Genetic Epidemiology

[37] Singapore Eye Research Institute,Department of Diabetes and Metabolic Diseases

[38] Singapore National Eye Centre,Department of Public Health and General Practice

[39] National University of Singapore,Department of Vascular Medicine

[40] Centro Cardiologico Monzino,Department of Medicine

[41] Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS),Department of Endocrinology

[42] University of Milan,Department of Medical Sciences

[43] Institut National de la Santé et de la Recherche Médicale (INSERM) Centre de recherche en Epidémiologie et Santé des Populations (CESP) U1018,Department of Community Health Sciences

[44] University Paris Sud 11,Department of Medicine

[45] UMRS 1018,Department of Pulmonary Physiology and Sleep Medicine

[46] Shanghai Diabetes Institute,Department of Epidemiology

[47] Shanghai Key Laboratory of Diabetes Mellitus,Department of Clinical Medicine

[48] Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Department of Biochemistry

[49] College of Medical and Dental Sciences,Department of Anthropology

[50] University of Birmingham,Department of Medicine

来源：

Nature Genetics | 2014年 / 46卷

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学科分类号：

摘要：

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

引用

页码：234 / 244

页数：10

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