Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

被引:0
|
作者
Anubha Mahajan
Min Jin Go
Weihua Zhang
Jennifer E Below
Kyle J Gaulton
Teresa Ferreira
Momoko Horikoshi
Andrew D Johnson
Maggie C Y Ng
Inga Prokopenko
Danish Saleheen
Xu Wang
Eleftheria Zeggini
Goncalo R Abecasis
Linda S Adair
Peter Almgren
Mustafa Atalay
Tin Aung
Damiano Baldassarre
Beverley Balkau
Yuqian Bao
Anthony H Barnett
Ines Barroso
Abdul Basit
Latonya F Been
John Beilby
Graeme I Bell
Rafn Benediktsson
Richard N Bergman
Bernhard O Boehm
Eric Boerwinkle
Lori L Bonnycastle
Noël Burtt
Qiuyin Cai
Harry Campbell
Jason Carey
Stephane Cauchi
Mark Caulfield
Juliana C N Chan
Li-Ching Chang
Tien-Jyun Chang
Yi-Cheng Chang
Guillaume Charpentier
Chien-Hsiun Chen
Han Chen
Yuan-Tsong Chen
Kee-Seng Chia
Manickam Chidambaram
Peter S Chines
Nam H Cho
机构
[1] Wellcome Trust Centre for Human Genetics,Department of Genome Sciences
[2] University of Oxford,Department of Public Health and Primary Care
[3] Center for Genome Science,Department of Epidemiology and Public Health
[4] National Institute of Health,Department of Biostatistics
[5] Osong Health Technology Administration Complex,Department of Nutrition
[6] Chungcheongbuk-do,Department of Clinical Science Malmö
[7] Cheongwon-gun,Department of Ophthalmology
[8] Gangoe-myeon,Department of Pharmacological Sciences
[9] Epidemiology and Biostatistics,Department of Endocrinology and Metabolism
[10] Imperial College London,Department of Pediatrics
[11] University of Washington,Department of Medicine
[12] Oxford Centre for Diabetes,Department of Human Genetics
[13] Endocrinology and Metabolism,Department of Internal Medicine, Division of Endocrinology and Diabetes
[14] University of Oxford,Department of Medicine
[15] National Heart,Department of Medicine and Therapeutics
[16] Lung and Blood Institute's Framingham Heart Study,Department of Internal Medicine
[17] Center for Genomics and Personalized Medicine Research,Department of Biostatistics
[18] Wake Forest School of Medicine,Department of Molecular Genetics
[19] Center for Diabetes Research,Department of Preventive Medicine
[20] Wake Forest School of Medicine,Department of Internal Medicine
[21] Genomics of Common Disease,Department of Nutrition and Epidemiology
[22] Imperial College London,Department of Biostatistics
[23] Hammersmith Hospital,Division of Cardiovascular Epidemiology
[24] University of Cambridge,Department of Dietetics
[25] Center for Non-Communicable Diseases Pakistan,Nutrition
[26] National University of Singapore,Department of Genetic Medicine and Development
[27] Wellcome Trust Sanger Institute,Department of Statistics
[28] Hinxton,Department of Epidemiology
[29] University of Michigan,Department of Chronic Disease Prevention
[30] University of North Carolina,Department of General Practice and Primary Health Care
[31] Lund University Diabetes Centre,Division of Genetics and Endocrinology
[32] Scania University Hospital,Department of Medicine
[33] Lund University,Division of Endocrinology and Metabolism
[34] Institute of Biomedicine,Department of Epidemiology
[35] University of Eastern Finland,Department of Medicine Solna
[36] Kuopio Campus,Department of Twin Research and Genetic Epidemiology
[37] Singapore Eye Research Institute,Department of Diabetes and Metabolic Diseases
[38] Singapore National Eye Centre,Department of Public Health and General Practice
[39] National University of Singapore,Department of Vascular Medicine
[40] Centro Cardiologico Monzino,Department of Medicine
[41] Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS),Department of Endocrinology
[42] University of Milan,Department of Medical Sciences
[43] Institut National de la Santé et de la Recherche Médicale (INSERM) Centre de recherche en Epidémiologie et Santé des Populations (CESP) U1018,Department of Community Health Sciences
[44] University Paris Sud 11,Department of Medicine
[45] UMRS 1018,Department of Pulmonary Physiology and Sleep Medicine
[46] Shanghai Diabetes Institute,Department of Epidemiology
[47] Shanghai Key Laboratory of Diabetes Mellitus,Department of Clinical Medicine
[48] Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Department of Biochemistry
[49] College of Medical and Dental Sciences,Department of Anthropology
[50] University of Birmingham,Department of Medicine
来源
Nature Genetics | 2014年 / 46卷
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摘要
Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.
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页码:234 / 244
页数:10
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