Prion diseases: Update on mad cow disease, variant Creutzfeldt-Jakob disease, and the transmissible spongiform encephalopathies

被引：8
作者：
Janka J. [1 ]
Maldarelli F. [1 ]
机构：
[1] NCI, National Institutes of Health, Bethesda, MD 20892
来源：
Current Infectious Disease Reports | 2004年 / 6卷 / 4期
关键词：
Prion Protein; Prion Disease; Bovine Spongiform Encephalopathy; Scrapie; Transmissible Spongiform Encephalopathy;
D O I：
10.1007/s11908-004-0053-y
中图分类号：
学科分类号：
摘要：
Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of infectious disease with disease transmission in the absence of nucleic acid. Several small but spectacular epidemics of TSEs in man have prompted widespread public health and food safety concerns. Although TSEs affect a comparatively small number of individuals, prion research has revealed fascinating insights of direct relevance to common illnesses. This paper reviews recent advances that have shed new light on the nature of prions and TSEs. Copyright © 2004 by Current Science Inc.
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页码：305 / 315
页数：10
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