Cross talk between natural killer cells and mast cells in tumor angiogenesis

被引:0
作者
Domenico Ribatti
Roberto Tamma
Enrico Crivellato
机构
[1] University of Bari Medical School,Department of Basic Medical Sciences, Neurosciences and Sensory Organs
[2] University of Udine,Department of Medicine, Section of Human Anatomy
来源
Inflammation Research | 2019年 / 68卷
关键词
Angiogenesis; Anti-angiogenesis; Mast cells; NK cells; Tumor growth;
D O I
暂无
中图分类号
学科分类号
摘要
Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. Under pathological conditions and during inflammation, NK cells extravasate into the lymph nodes and accumulate at inflammatory or tumor sites. The activation of NK cells depends on an intricate balance between activating and inhibitory signals that determines if a target will be susceptible to NK-mediated lysis. Many experimental evidences indicate that NK cells are also involved in several immunoregulatory processes and have the ability to modulate the adaptive immune responses. Many other important aspects about NK cell biology are emerging in these last years. The aim of this review is to elucidate the role of NK cells in tumor angiogenesis and their interaction with mast cells. In fact, it has been observed that NK cells produce pro-angiogenic factors and participate alone or in cooperation with mast cells to the regulation of angiogenesis in both physiological and pathological conditions including tumors.
引用
收藏
页码:19 / 23
页数:4
相关论文
共 50 条
  • [31] Uterine natural killer cells and angiogenesis in recurrent reproductive failure
    Quenby, Siobhan
    Nik, Helena
    Innes, Barbara
    Lash, Gendie
    Turner, Mark
    Drury, Jo
    Bulmer, Judith
    HUMAN REPRODUCTION, 2009, 24 (01) : 45 - 54
  • [32] The Role of Natural Killer Cells and Mast Cells in Female Infertility and Associated Treatment Outcomes
    Lorzadeh, Nahid
    Kazemirad, Nastaran
    CURRENT WOMENS HEALTH REVIEWS, 2020, 16 (02) : 102 - 106
  • [33] Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis
    de Souza Junior, Devandir Antonio
    Mazucato, Vivian Marino
    Santana, Ana Carolina
    Oliver, Constance
    Jamur, Maria Celia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (12)
  • [34] The cross talk between cervical carcinoma cells and vascular endothelial cells mediated by IL-27 restrains angiogenesis
    Zhang, Bing
    Xie, Feng
    Dong, Chun-Lin
    Gu, Chun-Jie
    Cheng, Jiao
    Wang, Yuan
    Xu, Xi-Zhong
    Pu, Hong
    Wu, Yi-Bo
    Qi, Xiao-Wei
    Li, Da-Jin
    Yu, Jin-Jin
    Li, Ming-Qing
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2017, 78 (04)
  • [35] Mast Cells in the Tumor Microenvironment
    Aponte-Lopez, Angelica
    Munoz-Cruz, Samira
    TUMOR MICROENVIRONMENT: HEMATOPOIETIC CELLS, PT B, 2020, 1273 : 159 - 173
  • [36] Mast cells and angiogenesis in pancreatic ductal adenocarcinoma
    Longo, Vito
    Tamma, Roberto
    Brunetti, Oronzo
    Pisconti, Salvatore
    Argentiero, Antonella
    Silvestris, Nicola
    Ribatti, Domenico
    CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 18 (03) : 319 - 323
  • [37] Mast cells and angiogenesis in pancreatic ductal adenocarcinoma
    Vito Longo
    Roberto Tamma
    Oronzo Brunetti
    Salvatore Pisconti
    Antonella Argentiero
    Nicola Silvestris
    Domenico Ribatti
    Clinical and Experimental Medicine, 2018, 18 : 319 - 323
  • [38] Different subpopulations of macrophages, neutrophils, mast cells, and fibroblasts are involved in the control of tumor angiogenesis
    Ribatti, Domenico
    FRONTIERS IN MEDICINE, 2024, 11
  • [39] Immunohistochemical evaluation of tumor angiogenesis and the role of mast cells in oral squamous cell carcinoma
    Kabiraj, Arpita
    Jaiswal, Rohit
    Singh, Anil
    Gupta, Jagriti
    Singh, Arun
    Samadi, Fahad M.
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2018, 14 (03) : 495 - 502
  • [40] Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases
    Puxeddu, I
    Ribatti, D
    Crivellato, E
    Levi-Schaffer, F
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (03) : 531 - 536