Neuropsychological testing and biomarkers in the management of brain metastases

被引：0
作者：
Andrew Baschnagel
Pamela L Wolters
Kevin Camphausen
机构：
[1] National Cancer Institute,Radiation Oncology Branch
[2] National Institutes of Health,Medical Illness Counseling Center and National Cancer Institute
[3] National Institutes of Health,undefined
来源：
Radiation Oncology | / 3卷
关键词：
Brain Metastasis; Neuropsychological Test; Karnofsky Performance Status; Whole Brain Radiation Therapy; Neurocognitive Impairment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prognosis for patients with brain metastasis remains poor. Whole brain radiation therapy is the conventional treatment option; it can improve neurological symptoms, prevent and improve tumor associated neurocognitive decline, and prevents death from neurologic causes. In addition to whole brain radiation therapy, stereotactic radiosurgery, neurosurgery and chemotherapy also are used in the management of brain metastases. Radiosensitizers are now currently being investigated as potential treatment options. All of these treatment modalities carry a risk of central nervous system (CNS) toxicity that can lead to neurocognitive impairment in long term survivors. Neuropsychological testing and biomarkers are potential ways of measuring and better understanding CNS toxicity. These tools may help optimize current therapies and develop new treatments for these patients. This article will review the current management of brain metastases, summarize the data on the CNS effects associated with brain metastases and whole brain radiation therapy in these patients, discuss the use of neuropsychological tests as outcome measures in clinical trials evaluating treatments for brain metastases, and give an overview of the potential of biomarker development in brain metastases research.
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  • [1] Johnson JD(1996)Demographics of brain metastasis Neurosurg Clin N Am 7 337-344
  • [2] Young B(1981)Intracerebral metastases in solid-tumor patients: natural history and results of treatment Cancer 48 384-394
  • [3] Zimm S(1980)Radiation therapy for brain metastases Ann Neurol 7 529-541
  • [4] Wampler GL(1980)The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 6 1-9
  • [5] Stablein D(1999)Identification of prognostic factors in patients with brain metastases: a review of 1292 patients Int J Radiat Oncol Biol Phys 43 795-803
  • [6] Hazra T(1998)Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial Jama 280 1485-1489
  • [7] Young HF(1997)Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 745-751
  • [8] Cairncross JG(2001)Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method Int J Radiat Oncol Biol Phys 51 426-434
  • [9] Kim JH(2007)Validation of the RTOG recursive partitioning analysis (RPA) classification for small-cell lung cancer-only brain metastases Int J Radiat Oncol Biol Phys 67 240-243
  • [10] Posner JB(2007)Brain metastases from breast carcinoma: validation of the radiation therapy oncology group recursive partitioning analysis classification and proposition of a new prognostic score Int J Radiat Oncol Biol Phys 69 839-845
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