Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

[1] Sharma P(2015)Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential Cell 161 205-214

[2] Allison JP(2018)Cancer immunotherapy using checkpoint blockade Science 359 1350-1355

[3] Ribas A(2008)Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity Science 322 1097-1100

[4] Wolchok JD(2019)Tuning the tumor myeloid microenvironment to fight cancer Front Immunol 10 1611-830 e14

[5] Hildner K(2018)The immune landscape of cancer Immunity 48 812-51

[6] Edelson BT(2017)Dendritic cells in cancer: the role revisited Curr Opin Immunol 45 43-164

[7] Purtha WE(2017)The CD47-SIRPalpha signaling axis as an innate immune checkpoint in cancer Immunol Rev 276 145-184

[8] Diamond M(2018)SIRPalpha-CD47 immune checkpoint blockade in anticancer therapy Trends Immunol 39 173-1215

[9] Matsushita H(2015)CD47 blockade triggers T cell-mediated destruction of immunogenic tumors Nat Med 21 1209-2554

[10] Kohyama M(2001)Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation J Immunol 167 2547-10036

[1] Sharma P(2015)Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential Cell 161 205-214

[2] Allison JP(2018)Cancer immunotherapy using checkpoint blockade Science 359 1350-1355

[3] Ribas A(2008)Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity Science 322 1097-1100

[4] Wolchok JD(2019)Tuning the tumor myeloid microenvironment to fight cancer Front Immunol 10 1611-830 e14

[5] Hildner K(2018)The immune landscape of cancer Immunity 48 812-51

[6] Edelson BT(2017)Dendritic cells in cancer: the role revisited Curr Opin Immunol 45 43-164

[7] Purtha WE(2017)The CD47-SIRPalpha signaling axis as an innate immune checkpoint in cancer Immunol Rev 276 145-184

[8] Diamond M(2018)SIRPalpha-CD47 immune checkpoint blockade in anticancer therapy Trends Immunol 39 173-1215

[9] Matsushita H(2015)CD47 blockade triggers T cell-mediated destruction of immunogenic tumors Nat Med 21 1209-2554

[10] Kohyama M(2001)Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation J Immunol 167 2547-10036