Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations

被引：0
作者：
A. M. W. Coppus
D. Fekkes
W. M. A. Verhoeven
S. Tuinier
C. M. van Duijn
机构：
[1] Dichterbij,Centre for the Intellectually Disabled
[2] Erasmus University Medical Centre,Department of Epidemiology
[3] Erasmus University Medical Centre,Department of Neuroscience
[4] Vincent van Gogh Institute for Psychiatry,Department of Psychiatry
[5] Erasmus University Medical Centre,undefined
来源：
Amino Acids | 2010年 / 38卷
关键词：
Amino acids; Down syndrome; Neopterin; Nitric oxide; Branched chain amino acids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Subjects with Down syndrome (DS) have abnormalities in virtually all aspects of the immune system and almost all will be affected with Alzheimer’s disease (AD). It is thought that nitric oxide (NO) is involved in the pathophysiology of AD. In the present study, including a total of 401 elderly DS subjects, the spectrum of plasma amino acids and neopterin was investigated and related to development of AD. Concentrations of nearly all amino acids in DS subjects differed significantly from those of healthy controls. Neopterin was increased in DS subjects, especially in dementia. The production of NO as reflected by an increased citrulline/arginine ratio (Cit/Arg ratio) was enhanced during development of clinical dementia. Neopterin concentrations correlated to the Cit/Arg ratio only in the group of prevalent demented subjects (ρ = 0.48, P = 0.006). The results of this study are suggestive for an increase in oxidative processes in DS subjects with AD.
引用
收藏
页码：923 / 928
页数：5
相关论文
共 129 条
  • [1] Akomolafe A(2006)Genetic association between endothelial nitric oxide synthase and Alzheimer disease Clin Genet 1 49-56
  • [2] Lunetta KL(2004)Nitric oxide as a physiopathological factor in neuropsychiatric disorders In Vivo 3 377-390
  • [3] Erlich PM(1997)Diagnosis of dementia in individuals with intellectual disability J Intellect Disabil Res 41 152-164
  • [4] Cupples LA(2005)Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleus Cell Mol Biol (Noisy-le-grand) 3 279-284
  • [5] Baldwin CT(2000)Test battery for the diagnosis of dementia in individuals with intellectual disability: working group for the establishment of criteria for the diagnosis of dementia in individuals with intellectual disability J Intellect Disabil Res 44 175-180
  • [6] Huyck M(2008)Protein expression of BACE1, BACE2 and APP in Down syndrome brains Amino Acids 35 339-343
  • [7] Green RC(2006)Dementia and mortality in persons with Down’s syndrome J Intellect Disabil Res 50 768-777
  • [8] Farrer LA(2007)Plasma amino acids and neopterin in healthy persons with Down’s syndrome J Neural Transm 8 1041-1045
  • [9] Akyol O(1995)Validation of the determination of amino acids in plasma by high-performance liquid chromatography using automated pre-column derivatization with J Chromatogr B Biomed Appl 2 177-186
  • [10] Zoroglu SS(2007)-phthaldialdehyde Amino Acids 1 121-126
12345678910