Genomic signatures of domestication in Old World camels

被引：0

作者：

Robert Rodgers Fitak

Elmira Mohandesan

Jukka Corander

Adiya Yadamsuren

Battsetseg Chuluunbat

Omer Abdelhadi

Abdul Raziq

Peter Nagy

Chris Walzer

Bernard Faye

Pamela Anna Burger

机构：

[1] Vetmeduni Vienna,Institute of Population Genetics

[2] University of Vienna,Department of Evolutionary Anthropology

[3] Wellcome Sanger Institute,Helsinki Institute for Information Technology, Department of Mathematics and Statistics

[4] University of Helsinki,Department of Biostatistics

[5] University of Oslo,Institute of Remote Sensing and Digital Earth

[6] Chinese Academy of Sciences,Laboratory of Genetics, Institute of General and Experimental Biology

[7] Wild Camel Protection Foundation Mongolia. Jukov avenue,Farm and Veterinary Department

[8] Mongolian Academy of Sciences,Wildlife Conservation Society

[9] University of Khartoum,Research Institute of Wildlife Ecology

[10] Department for Meat Sciences,Department of Biology, Genomics and Bioinformatics Cluster

[11] Camelait,undefined

[12] Alain Farms for Livestock Production,undefined

[13] Emirates Industry for Camel Milk and Products,undefined

[14] Wildlife Health Program,undefined

[15] Vetmeduni Vienna,undefined

[16] CIRAD-ES,undefined

[17] UMR 112,undefined

[18] Campus International de Baillarguet,undefined

[19] TA C/112A,undefined

[20] University of Central Florida,undefined

来源：

Communications Biology | / 3卷

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摘要：

Domestication begins with the selection of animals showing less fear of humans. In most domesticates, selection signals for tameness have been superimposed by intensive breeding for economical or other desirable traits. Old World camels, conversely, have maintained high genetic variation and lack secondary bottlenecks associated with breed development. By re-sequencing multiple genomes from dromedaries, Bactrian camels, and their endangered wild relatives, here we show that positive selection for candidate genes underlying traits collectively referred to as ‘domestication syndrome’ is consistent with neural crest deficiencies and altered thyroid hormone-based signaling. Comparing our results with other domestic species, we postulate that the core set of domestication genes is considerably smaller than the pan-domestication set – and overlapping genes are likely a result of chance and redundancy. These results, along with the extensive genomic resources provided, are an important contribution to understanding the evolutionary history of camels and the genomic features of their domestication.

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