A nanoporous interferometric micro-sensor for biomedical detection of volatile sulphur compounds

被引：0
作者：
Tushar Kumeria
Luke Parkinson
Dusan Losic
机构：
[1] University of South Australia,Ian Wark Research Institute
来源：
Nanoscale Research Letters | / 6卷
关键词：
nanoporous alumina; reflectometric interference spectroscopy; volatile sulphur compounds; hydrogen sulphide sensor; oral malodour;
D O I：
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摘要：
This work presents the use of nanoporous anodic aluminium oxide [AAO] for reflective interferometric sensing of volatile sulphur compounds and hydrogen sulphide [H2S] gas. Detection is based on changes of the interference signal from AAO porous layer as a result of specific adsorption of gas molecules with sulphur functional groups on a gold-coated surface. A nanoporous AAO sensing platform with optimised pore diameters (30 nm) and length (4 µm) was fabricated using a two-step anodization process in 0.3 M oxalic, followed by coating with a thin gold film (8 nm). The AAO is assembled in a specially designed microfluidic chip supported with a miniature fibre optic system that is able to measure changes of reflective interference signal (Fabry-Perrot fringes). When the sensor is exposed to a small concentration of H2S gas, the interference signal showed a concentration-dependent wavelength shifting of the Fabry-Perot interference fringe spectrum, as a result of the adsorption of H2S molecules on the Au surface and changes in the refractive index of the AAO. A practical biomedical application of reflectometric interference spectroscopy [RIfS] Au-AAO sensor for malodour measurement was successfully shown. The RIfS method based on a nanoporous AAO platform is simple, easy to miniaturise, inexpensive and has great potential for development of gas sensing devices for a range of medical and environmental applications.
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  • [1] Beauchamp RO(1984)A critical review of the literature on hydrogen sulfide toxicity CRC Crit Rev Toxicol 13 25-97
  • [2] Bus JS(2010)The redox biochemistry of hydrogen sulfide J Biol Chem 285 21903-21907
  • [3] Popp JA(1996)The possible role of hydrogen sulphide as an endogenous neuromodulator J Neurosci 16 1066-1071
  • [4] Boreiko CJ(2006)The relationship between oral malodor and volatile sulfur compound-producing bacteria Otolaryngol Head Neck Surg 135 671-676
  • [5] Andjelkovich DA(1999)Simple detector for oral malodour based on spectrofluorimetric measurements of hydrogen sulphide in mouth air Anal Chim Acta 398 23-31
  • [6] Leber P(2002)Optical fibre sensor for hydrogen sulfide monitoring in mouth air Anal Chim Acta 471 13-23
  • [7] Kabil O(2008)Oral malodour--a review Arch Oral Biol 53 S1-S7
  • [8] Banerjee R(2004)Study on the organoleptic intensity scale for measuring oral malodor J Dental Res 83 81-85
  • [9] Abe K(2010)Fluorescein mercuric acetate--a novel sensor for oral malodour detection Sens Act B 148 54-58
  • [10] Kimura H(2010)Novel colorimetric sensor for oral malodour Anal Chim Acta 661 97-102
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