Virtual terminator nucleotides for next-generation DNA sequencing

被引：0
作者：
Jayson Bowers
Judith Mitchell
Eric Beer
Philip R Buzby
Marie Causey
J William Efcavitch
Mirna Jarosz
Edyta Krzymanska-Olejnik
Li Kung
Doron Lipson
Geoffrey M Lowman
Subramanian Marappan
Peter McInerney
Adam Platt
Atanu Roy
Suhaib M Siddiqi
Kathleen Steinmann
John F Thompson
机构：
[1] Helicos BioSciences Corporation,
来源：
Nature Methods | 2009年 / 6卷
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摘要：
Nucleotide analogs modified with a free 3′ hydroxyl, maintaining the interactions at the polymerase active site, and a cleavable linker, attaching a fluorescent dye and an inhibitor, are efficient at reading homopolymer runs in a single-molecule sequencing reaction.
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页码：593 / 595
页数：2
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