Effect of Gold Nanoparticles Coated with Plasma Components on ADP-Induced Platelet Aggregation

被引：0
作者：
A. V. Aseychev
O. A. Azizova
E. M. Beckman
L. B. Dudnik
V. I. Sergienko
机构：
[1] Laboratory of Biophysical Bases of Pathology,
[2] Russian Federal Medical Biological Agency,undefined
[3] Research Institute of Physicochemical Medicine,undefined
[4] Russian Federal Medical Biological Agency,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2013年 / 155卷
关键词：
gold nanoparticles; coating; platelets; aggregation; biosafety;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5–40 μM) and particle size (5–30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.
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页码：685 / 688
页数：3
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