Pre- and post-translational regulation of osteopontin in cancer

被引：0
作者：
Pieter H. Anborgh
Jennifer C. Mutrie
Alan B. Tuck
Ann F. Chambers
机构：
[1] London Regional Cancer Program,Department of Pathology
[2] University of Western Ontario,Department of Oncology
[3] London Health Sciences Centre,undefined
[4] University of Western Ontario,undefined
来源：
Journal of Cell Communication and Signaling | 2011年 / 5卷
关键词：
Osteopontin; Cancer; Metastasis; Matricellular protein; Post-translational modification; Alternative splicing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors including integrins and CD44. It is expressed in many tissues and secreted into body fluids including blood, milk and urine. OPN plays important physiological roles in bone remodeling, immune response and inflammation. It is also a tumour-associated protein, and elevated OPN levels are associated with tumour formation, progression and metastasis. Research has revealed a promising role for OPN as a cancer biomarker. OPN is subject to alternative splicing, as well as post-translational modifications such as phosphorylation, glycosylation and proteolytic cleavage. Functional differences have been revealed for different isoforms and post-translational modifications. The pattern of isoform expression and post-translational modification is cell-type specific and may influence the potential role of OPN in malignancy and as a cancer biomarker.
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页码：111 / 122
页数：11
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