Prolapse into the bile duct and expansive growth is characteristic behavior of mucinous cystic neoplasm of the liver: report of two cases and review of the literature

被引：17

作者：

Takano Y. ^{[1
]}

Nagahama M. ^{[1
]}

Yamamura E. ^{[1
]}

Maruoka N. ^{[1
]}

Mizukami H. ^{[2
]}

Tanaka J.-I. ^{[2
]}

Ohike N. ^{[3
]}

Takahashi H. ^{[1
]}

机构：

[1] Division of Gastroenterology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama-shi, Yokohama, 227-8501, Kanagawa

[2] Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Kanagawa

[3] Department of Diagnostic Pathology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa

来源：

Clinical Journal of Gastroenterology | 2015年 / 8卷 / 3期

关键词：

Biliary cystadenoma; ERCP; Mucinous cystic neoplasm of the liver; Ovarian-like stroma;

D O I：

10.1007/s12328-015-0569-8

中图分类号：

学科分类号：

摘要：

Mucinous cystic neoplasm of the liver (MCN-L) is a very rare tumor whose detailed behavior is still unknown. We describe two cases of MCN-L that exhibited extremely interesting growth patterns, and discuss the characteristics of MCN-Ls. Both cases exhibited MCN-L that originated from the left hepatic lobe (Segment 4) and then prolapsed into the left hepatic duct and common bile duct, resulting in obstructive jaundice due to expansive growth. Endoscopic retrograde cholangiopancreatographies showed the characteristic oval-shaped filling defects in the bile ducts. Endoscopic ultrasound and intraductal ultrasound were useful for differentiating the tumors from stones, since multiple septal formations were observed inside the tumors. A literature search revealed that, over the past 10 years, 15 cases of MCN-L (biliary cystadenomas with ovarian-like stroma) that showed expansive growth in the bile duct had been reported. Prolapse into the bile duct and expansive growth appear to be characteristic behavior of MCN-L. In the future, additional data on more cases needs to be collected to further elucidate MCN-L pathophysiology. © 2015, The Author(s).

引用

页码：148 / 155

页数：7

共 29 条

[1]

Nakanuma Y., Curado M.-P., Franceschi S., Et al., WHO classification of tumours of the digestive system, pp. 217-224, (2010)

[2]

Zen Y., Pedica F., Patcha V.R., Et al., Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct, Mod Pathol, 24, pp. 1079-1089, (2011)

[3]

Wheeler D.A., Edmondson H.A., Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change, Cancer, 56, pp. 1434-1445, (1985)

[4]

Nakanuma Y., Sasaki M., Ishikawa A., Et al., Biliary papillary neoplasm of the liver, Histol Histopathol, 17, pp. 851-861, (2002)

[5]

Li T., Ji Y., Zhi X.T., Et al., A comparison of hepatic mucinous cystic neoplasms with biliary intraductal papillary neoplasms, Clin Gastroenterol Hepatol, 7, pp. 586-593, (2009)

[6]

Nakanuma Y., Zen Y., Harada K., Et al., Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach, J Hepatobiliary Pancreat Sci, 17, pp. 211-222, (2010)

[7]

Lim J.H., Zen Y., Jang K.T., Et al., Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects, Am J Roentgenol, 197, pp. 1111-1120, (2011)

[8]

Takanami K., Yamada T., Tsuda M., Et al., Intraductal papillary mucinous neoplasm of the bile ducts: multimodality assessment with pathologic correlation, Abdom Imaging, 36, pp. 447-456, (2011)

[9]

Zen Y., Jang K.T., Ahn S., Et al., Intraductal papillary neoplasms and mucinous cystic neoplasms of the hepatobiliary system: demographic differences between Asian and Western populations, and comparison with pancreatic counterparts, Histopathology, 65, pp. 164-173, (2014)

[10]

Crippa S., Salvia R., Warshaw A.L., Et al., Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients, Ann Surg, 247, pp. 571-579, (2008)

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