Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

被引：17

作者：

Sadat Alavi M. ^{[1
]}

Azarpira N. ^{[2
]}

机构：

[1] Department of Nuclear Medicine, Shiraz University of Medical Sciences, Shiraz

[2] Department of Pathology, Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz

来源：

Journal of Medical Case Reports | / 5卷 / 1期

关键词：

Thyroid Carcinoma; Papillary Thyroid Carcinoma; Thyroglobulin; Medullary Thyroid Carcinoma; Collision Tumor;

D O I：

10.1186/1752-1947-5-590

中图分类号：

学科分类号：

摘要：

Introduction. Papillary thyroid carcinoma and medullary thyroid carcinoma are two different thyroid neoplasia. The simultaneous occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma as a collison tumor with metastases from both lesions in the regional lymph nodes is a rare phenomenon. Case presentation. A 32-year-old Iranian man presented with a fixed anterior neck mass. Ultrasonography revealed two separate thyroid nodules as well as a suspicious neck mass that appeared to be a metastatic lesion. The results of thyroid function tests were normal, but the preoperative calcitonin serum value was elevated. Our patient underwent a total thyroidectomy with neck exploration. Two separate and ill-defined solid lesions grossly in the right lobe were noticed. Histological and immunohistochemical studies of these lesions suggested the presence of medullary thyroid carcinoma and papillary thyroid carcinoma. The lymph nodes isolated from a neck dissection specimen showed metastases from both lesions. Conclusions: The concomitant occurrence of papillary thyroid carcinoma and medullary thyroid carcinoma and the exact diagnosis of this uncommon event are important. The treatment strategy should be reconsidered in such cases, and genetic screening to exclude multiple endocrine neoplasia 2 syndromes should be performed. For papillary thyroid carcinoma, radioiodine therapy and thyroid-stimulating hormone suppressive therapy are performed. However, the treatment of medullary thyroid carcinoma is mostly radical surgery with no effective adjuvant therapy. © 2011 Sadat Alavi and Azarpira; licensee BioMed Central Ltd.

引用

共 24 条

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