Effects of Endogenous and Exogenous Glucocorticoids on Liver Differentiation

被引：0
作者：
Celia Machín
Carmen Rúa
Begoña Diaz
Rosa María Arahuetes
机构：
[1] Ciudadad Universitaria,Dpto. Biología Celular
[2] Ciudadad Universitaria,Dpto. Biología Animal II. Facultad C. C. Biológicas Universidad Complutense
来源：
Acta Biologica Hungarica | 2001年 / 52卷
关键词：
Fetal liver; glucocorticoids; adrenalectomy;
D O I：
暂无
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学科分类号：
摘要：
The effects of maternal bilateral adrenalectomy on day 1 of gestation and betamethasone treatment on fetal liver development were compared, in terms of biochemical and morphological parameters. For fetuses 20 days old (E20), absence of maternal glucocorticoids during gestation caused an increase in the number of nuclei in whole livers, and a significantly decrease of both body weight and protein content per nucleus, in comparison with the control group (C). Betamethasone injection on days 15, 16 and 17 of gestation into adrenalectomized pregnant rats (ADX + BET) did not completely prevent these effects.
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页码：63 / 74
页数：11
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