Models of hydration and isomeric transitions of glucose molecules in aqueous solutions

The kinematic viscosity of aqueous glucose solutions is studied. It is found that the hydrodynamic radius of monosaccharide molecule in an aqueous solution depends on temperature in the range of 290–355 K. Using a bimodal model of the energy states of the volume in which the glucose molecule is located and local equilibrium is established, it is shown that the above-mentioned dependence can be attributed to disturbances in the equilibrium of isomeric transitions, induced by variations in temperature. The parameters of isomeric transitions for a glucose molecule in an aqueous solvent, the probability of “chair” and “boat” configurations occurring for glucose molecules, and the number of water molecules in the hydration shells of these configurations are calculated; the strain of the chemical bonds in the chair configuration of a glucose molecule is estimated.