Nucleophilic trifluoromethoxylation of alkyl halides without silver

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作者：
Yan Li
Yang Yang
Jinrui Xin
Pingping Tang
机构：
[1] Nankai University,State Key Laboratory and Institute of Elemento
来源：
Nature Communications | / 11卷
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摘要：
The biological properties of molecules containing the trifluoromethoxy group have made these compounds important targets in pharmaceuticals and agrochemicals, yet their preparation is still a substantial challenge. Herein, we present a practical nucleophilic trifluoromethoxylation of alkyl halides with (E)-O-trifluoromethyl-benzaldoximes (TFBO) as a trifluoromethoxylation reagent in the absence of silver under mild reaction conditions. The trifluoromethoxylation reagent TFBO is easily prepared and thermally stable, and can release CF3O− species in the presence of a base. Furthermore, broad scope and good functional group compatibility are demonstrated by application of the method to the late-stage trifluoromethoxylation of alkyl halides in complex small molecules.
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