Effects on the pulmonary hemodynamics and gas exchange with a speed modulated right ventricular assist rotary blood pump: a numerical study

Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and more research has focused on the pulsatile modulation of RBPs in an attempt to provide better perfusion. In this study, we investigated the effects of an axial RBP serving as the right ventricular assist device on pulmonary hemodynamics and gas exchange using a numerical method with a complete cardiovascular model along with airway mechanics and a gas exchange model. The RBP runs in both constant speed and synchronized pulsatile modes using speed modulation. Hemodynamics and airway O2 and CO2 partial pressures were obtained under normal physiological conditions, and right ventricle failure conditions with or without RBP. Our results showed that the pulsatile mode of the RBP could support right ventricular assist to restore most hemodynamics. Using speed modulation, both pulmonary arterial pressure and flow pulsatility were increased, while there was only very little effect on alveolar O2 and CO2 partial pressures. This study could provide basic insight into the influence of pulmonary hemodynamics and gas exchange with speed modulated right ventricular assist RBPs, which is concerned when designing their pulsatile control methods.